Amino-pyrimidine skeletal muscle modulators

Patent metadata

Field	Value
Publication number	US-10272030-B2
Application number	US-201715645977-A
Country	US
Kind code	B2
Filing date	Jul 10, 2017
Priority date	Apr 23, 2010
Publication date	Apr 30, 2019
Grant date	Apr 30, 2019

Abstract

Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

First claim

What is claimed is:

1. A method for treating a disease or condition selected from the group consisting of neuromuscular disorders, conditions of muscle wasting, muscular myopathies, rehabilitation-related deficits, muscle atrophy and fatigue, metabolic syndrome, chronic fatigue syndrome, Amyotrophic Lateral Sclerosis (ALS), Spinal Muscular Atrophy (SMA), myasthenia gravis, peripheral vascular disease, peripheral arterial disease, chronic pulmonary obstructive disorder (COPD), heart failure, frailty, and obesity, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein the disease or condition is Amyotrophic Lateral Sclerosis (ALS).

3. The method of claim 1 , wherein the disease or condition is Spinal Muscular Atrophy (SMA).

4. The method of claim 1 , wherein the disease or condition is myasthenia gravis.

5. The method of claim 1 , wherein the disease or condition is peripheral vascular disease or peripheral arterial disease.

6. The method of claim 1 , wherein the disease or condition is chronic pulmonary obstructive disorder (COPD).

7. The method of claim 1 , wherein the disease or condition is heart failure.

8. The method of claim 1 , wherein the disease or condition is frailty.

Assignees

• Cytokinetics Inc

Inventors

• Yang Zhe
• Muci Alex R
• Warrington Jeffrey
• Bergnes Gustave
• Morgan Bradley P
• Chuang Chihyuan
• Romero Antonio
• Collibee Scott
• Qian Xiangping
• Lu Pu-Ping

Classifications

• A61P9/04

  Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title