Process for separation of diamines and/or omega-aminoacids from a feed fixture

Patent metadata

Field	Value
Publication number	US-10265642-B2
Application number	US-201615094770-A
Country	US
Kind code	B2
Filing date	Apr 8, 2016
Priority date	Apr 10, 2015
Publication date	Apr 23, 2019
Grant date	Apr 23, 2019

Abstract

The present disclosure relates to methods for separating at least one amine chosen from diamines and omega-aminoacids from a feed mixture using a simulated moving bed (SMB) adsorptive technology.

First claim

What is claimed is:

1. A process for separating at least one amine from at least one impurity in a feed mixture, comprising:
introducing into a simulated moving bed apparatus having one or more zones a feed mixture comprising a fermentation product comprising at least one amine chosen from C3-C12 diamines and C3-C12 linear aliphatic ω-aminoacids and at least one impurity,
wherein the at least one impurity comprises at least one component more polar than the at least one amine, at least one component less polar than the at least one amine, or at least one component more polar than the at least one amine and at least one component less polar than the at least one amine, and
wherein each zone of the simulated moving bed apparatus comprises at least one adsorbent stationary phase to separate the at least one amine from the at least one impurity based on differences in polarity; and
wherein at least one zone of the simulated moving bed apparatus comprises a non-ionic resin as at least one adsorbent stationary phase; and

recovering from the simulated moving bed apparatus a composition comprising the at least one amine with a purity higher than that in the feed mixture.

2. The process according to claim 1 further comprising:
subjecting the feed mixture to at least one solid-liquid separation prior to introducing the feed mixture into the simulated moving bed apparatus.

3. The process according to claim 2 , wherein the at least one solid-liquid separation is chosen from cross-flow filtration, centrifugation, and dead-end filtration.

4. The process according to claim 1 , wherein the fermentation product is produced by at least one organism chosen from Escherichia coli, Clostridium ljungdahlii, Clostridium autoethanogenum, Clostridium kluyveri, Corynebacterium glutamicum, Cupriavidus necator, Cupriavidusmetallidurans, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas oleavorans, Delftia acidovorans, Bacillus subtillis, Lactobacillus delbrueckii, Lactococcus lactis, Rhodococcus equi, Aspergillus niger; Saccharomyces cerevisiae, Pichia pastoris, Yarrowia lipolytica, Issathenkia orientalis, Debaryomyces hansenii, Arxula adenoinivorans , and Kluyveromyces lactis.

5. The process according to claim 1 , wherein the simulated moving bed apparatus comprises only one zone.

6. The process according to claim 1 , wherein the simulated moving bed apparatus comprises more than one zone.

7. The process according to claim 6 , further comprising
collecting from a column in a zone a raffinate stream comprising the at least one amine,
introducing the raffinate stream into a column of another zone; and
recovering the at least one amine from said another zone.

8. The process according to claim 6 , further comprising
collecting from a column in a zone an extract stream comprising the at least one amine,
introducing the extract stream into a column of another zone; and
recovering the at least one amine from said another zone.

9. The process according to claim 7 , wherein the raffinate stream is introduced into a column nonadjacent to the column from which the raffinate is collected.

10. The process according to claim 8 , wherein the extract stream is introduced into a column nonadjacent to the column from which the extract is collected.

11. The process according to claim 6 , wherein part of an extract stream and/or a raffinate stream from one zone is/are recycled back into the same zone or into a different zone upstream from the one zone.

12. The process according to claim 1 , wherein one or more eluents comprising at least one solvent chosen from water and alcohol is introduced in the simulating moving bed apparatus.

13. The process according to claim 1 , wherein the feed mixture comprises at least one C3-C12 diamine chosen from pentamethylenediamine, hexamethylenediamine, heptamethylenediamine, and 1,12-diaminododecane.

14. The process according to claim 1 , wherein the feed mixture comprises at least one C3-C12 linear ω-aminoacid chosen from 5-aminopentanoic acid, 6-aminocaproic acid, 7-aminoheptanoic acid, 11-aminoundecanoic acid, and 12-aminolauric acid.

15. The process according to claim 1 further comprising:
subjecting the composition recovered from the simulated moving bed apparatus to at least one separation step.

16. The process according to claim 15 , wherein the at least one separation step is chosen from evaporation, distillation, vacuum distillation, filtration, membrane separation, crystallization, evaporative crystallization, and cooling crystallization.

17. The process according to claim 1 , wherein the simulated moving bed apparatus comprises at least 4 columns.

18. The process according to claim 1 , further comprising:
introducing the feed mixture into at least one guard bed prior to introducing the feed mixture into the simulated moving bed apparatus.

19. The process according to claim 12 , further comprising:
feeding into at least one desorbent recovery process at least one raffinate stream and/or at least one extract stream.

20. The process according to claim 19 , wherein the at least one desorbent recovery process is chosen from evaporation, distillation, crystallization, vacuum crystallization, and cooling crystallization.

21. The process according to claim 12 , further comprising:
feeding into at least one water recovery process at least one raffinate stream containing water.

22. The process according to claim 21 , wherein the at least one water recovery process is chosen from evaporation, distillation, vacuum distillation, filtration, membrane separation, crystallization, evaporative crystallization, and cooling crystallization.

Assignees

• Invista North America Sarl

Inventors

• Smith Gary
• Kirby Gregory S
• Pearlman Paul

Classifications

• C07C209/86

  Separation · CPC title

• C12P13/005

  Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids · CPC title

• B01D15/1892

  the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds or centrifugal chromatography · CPC title

• C07C211/09

  Diamines · CPC title

• C07C227/38

  Separation; Purification; Stabilisation; Use of additives (separation of optical isomers C07C227/34) · CPC title