Agent for improving cancer cell adhesiveness
US-9372136-B2 · Jun 21, 2016 · US
US10258906B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10258906-B2 |
| Application number | US-201715409747-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 19, 2017 |
| Priority date | Oct 14, 2011 |
| Publication date | Apr 16, 2019 |
| Grant date | Apr 16, 2019 |
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A metal filter includes a plurality of through holes. An opening shape of each of the plurality of through holes is a rectangle or rounded-rectangle and a length of a short side of the rectangle or a rounded rectangle is 5 to 15 μm. A method for concentrating cancer cells using the metal filter includes separating cancer cells from blood and blood cell constituents by passing blood, red blood cells, white blood cells, and platelets through the plurality of through holes while capturing cancer cells to concentrate the cancer cells.
Opening claim text (preview).
The invention claimed is: 1. A method for concentrating cancer cells, comprising: providing a metal filter having a plurality of through holes, wherein an opening shape of each of the plurality of through holes is a rectangle or rounded-rectangle and a length of a short side of the rectangle or a rounded rectangle is 5 to 15 μm, the through holes have an average aperture ratio of 1% to 10%, and the metal filter comprises a metal selected from the group consisting of gold, silver, aluminum, tungsten, nickel, chrome, and an alloy of two or more of these metals, as a main constituent; and separating cancer cells from blood and blood cell constituents by passing blood, red blood cells, white blood cells, and platelets through the plurality of through holes while capturing cancer cells to concentrate the cancer cells. 2. The method for concentrating cancer cells according to claim 1 , wherein the thickness of the metal filter is 3 to 50 μm. 3. The method for concentrating cancer cells according to claim 1 , wherein an opening shape of each of the plurality of through holes is a rectangle. 4. The method for concentrating cancel cancer cells according claim 1 , wherein an opening shape of each of the plurality of through holes is a rounded-rectangle.
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