Injection device for delivery of a liquid medicament with medicament container displacement

Patent metadata

Field	Value
Publication number	US-10251997-B2
Application number	US-201415026708-A
Country	US
Kind code	B2
Filing date	Oct 16, 2014
Priority date	Oct 18, 2013
Publication date	Apr 9, 2019
Grant date	Apr 9, 2019

Abstract

The present invention relates to an injection device for dispensing of a liquid medicament, the device comprising: a base ( 10 ), a medicament reservoir ( 20 ) displaceably arranged on the base ( 10 ) and containing the liquid medicament ( 25 ), an injection needle ( 30 ) displaceably arranged relative to the base ( 10 ) between a retracted position ( 30 a ) and an extended position ( 30 b ), a pressure container ( 40 ) containing a pressurized fluid ( 24 ), a reservoir displacing arrangement ( 50 ) coupled with the pressure container ( 40 ) to displace the medicament reservoir ( 20 ) into a dispensing position ( 20 b ), in which the medicament reservoir ( 20 ) is in fluid communication with the injection needle ( 30 ), a needle displacing arrangement ( 60 ) coupled with the pressure container ( 40 ) to at least displace the injection needle ( 30 ) into the extended position ( 30 b ).

First claim

The invention claimed is:

1. An injection device for dispensing of a liquid medicament, the device comprising:
a base,
a medicament reservoir displaceably arranged on the base and containing the liquid medicament,
an injection needle displaceably arranged relative to the base between a retracted position and an extended position,
a pressure container containing a pressurized fluid,
a reservoir displacing mechanism coupled with the pressure container and configured to displace the medicament reservoir from an initial position, in which the medicament reservoir is not in fluid communication with the injection needle, into a dispensing position, in which the medicament reservoir is in fluid communication with the injection needle,
a needle displacing mechanism coupled with the pressure container and configured to at least displace the injection needle into the extended position, wherein the reservoir displacing mechanism and the needle displacing mechanism are separately connected with the pressure container, and
a stop member fixed to the base and configured to limit a displacement of the medicament reservoir relative to the base when the medicament reservoir reaches the dispensing position, wherein the stop member comprises a tipped piercing member to penetrate a distal outlet of the medicament reservoir when the medicament reservoir is in the dispensing position, wherein the piercing member is in fluid communication with the injection needle.

2. The injection device according to claim 1 , wherein the pressure container is sealed by an axially displaceable driving piston mechanically connected to a drive member of the needle displacing mechanism, wherein the driving piston is axially displaceable from an initial position into a first extended position and into a second extended position under the effect of the pressurized fluid.

3. The injection device according to claim 2 , wherein the drive member comprises at least one sliding block guide portion at least in sections extending at a predefined angle with respect to the axial direction and being engaged with a needle tappet connected to the injection needle.

4. The injection device according to claim 2 , wherein the injection needle is displaceable from the retracted position into the extended position by way of an axial displacement of the driving piston from an initial position to the first extended position.

5. The injection device according to claim 2 , wherein the injection needle is displaceable from the extended position into the retracted position by way of an axial displacement of the driving piston from the first extended position to the second extended position.

6. The injection device according to claim 2 , wherein the pressure container comprises a first outlet in fluid communication with the reservoir displacing mechanism, wherein the first outlet is sealed by the driving piston when the driving piston is in the initial position and wherein the first outlet is at least partially in fluid communication with the pressurized gas when the driving piston is in the first extended position.

7. The injection device according to claim 2 , wherein the reservoir displacing mechanism comprises:
a stop member, and
a driving unit hydraulically or pneumatically coupleable with the pressure container and comprising a driving chamber to slidably receive a proximal portion of the medicament reservoir.

8. The injection device according to claim 7 , wherein the medicament reservoir comprises a rigid body proximally sealed by a reservoir piston, which is displaceable in a medicament dispensing direction by way of the pressurized fluid flowing into the driving chamber of the driving unit of the reservoir displacing mechanism.

9. The injection device according to claim 2 , further comprising a locking member extending with a shaft portion through the needle displacing mechanism to block a distally directed displacement of the pressure container's driving piston.

10. The injection device according to claim 2 , further comprising a retraction mechanism mechanically engaged with a needle stopper to displace the needle stopper into a release position, in which the driving piston is displaceable into the second extended position.

11. The injection device according to claim 10 , wherein the retraction mechanism comprises a barrel sealed by a displaceable release piston operably engageable with the needle stopper, wherein the barrel comprises an inlet in fluid communication with a discharge outlet of the reservoir displacing mechanism.

12. The injection device according to claim 2 , wherein the pressure container comprises a second outlet in fluid communication with a signal generator, wherein the second outlet is at least partially in fluid communication with the pressurized fluid when the driving piston is in the second extended position, wherein the reservoir displacing mechanism and the needle displacing mechanism are separately connected with the pressure container.

13. The injection device according to claim 1 , further comprising at least one throttle arranged in a flow path between the pressure container and the medicament reservoir to control a rate of medicament dispensing.

14. An injection device for dispensing of a drug, the device comprising:
a base,
a medicament reservoir displaceably arranged on the base and containing a pharmaceutically active compound,
an injection needle displaceably arranged relative to the base between a retracted position and an extended position,
a pressure container containing a pressurized fluid,
a reservoir displacing mechanism coupled with the pressure container and configured to displace the medicament reservoir into a dispensing position, in which the medicament reservoir is in fluid communication with the injection needle, and
a needle displacing mechanism coupled with the pressure container and configured to at least displace the injection needle into the extended position, wherein the reservoir displacing mechanism and the needle displacing mechanism are separately connected with the pressure container,
wherein the pressure container is sealed by an axially displaceable driving piston mechanically connected to a drive member of the needle displacing mechanism, wherein the driving piston is axially displaceable from an initial position into a first extended position and into a second extended position under the effect of the pressurized fluid, and
wherein the pressure container comprises a first outlet in fluid communication with the reservoir displacing mechanism, wherein the first outlet is sealed by the driving piston when the driving piston is in the initial position and wherein the first outlet is at least partially in fluid communication with the pressurized gas when the driving piston is in the first extended position.

15. A method of operating an injection device, the method comprising:
removing a stop from a piston of a pressure container;
moving the piston of the pressure container with a pressurized fluid in the pressure container from a rest position to a first position in the pressure container, the first position fluidly coupling the pressurized fluid to a medicament reservoir;
displacing the medicament reservoir into abutment with a stop member being fixed to a base, the base comprising a tipped piercing member,
penetrating a distal outlet of the medicament by the tipped piercing member, wherein the tipped piercing member is in fluid communication with an injection needle;
advancing a needle through a base of the injection device as the piston moves to the first position;
moving the piston of the pressure

Assignees

• Sanofi Aventis Deutschland

Inventors

• Nessel Christian
• Auernhammer Daniel

Classifications

• A61M5/31501

  Means for blocking or restricting the movement of the rod or piston (A61M5/5013 takes precedence) · CPC title

• A61M2005/14252

  with needle insertion means · CPC title

• A61M5/155 Primary

  pressurised by gas {introduced into the reservoir} · CPC title

• A61M5/14248

  of the skin patch type · CPC title

• A61M5/14526 Primary

  the piston being actuated by fluid pressure · CPC title