Glucose sensor signal reliability analysis

Patent metadata

Field	Value
Publication number	US-10251588-B2
Application number	US-201514686653-A
Country	US
Kind code	B2
Filing date	Apr 14, 2015
Priority date	Oct 28, 2010
Publication date	Apr 9, 2019
Grant date	Apr 9, 2019

Abstract

Disclosed are methods, apparatuses, etc. for glucose sensor signal reliability analysis.

First claim

What is claimed is:

1. A method comprising:
obtaining a plurality of glucose sensor measurements at a glucose sensor over a time interval by receiving an electrical current generated by the glucose sensor during a time that the glucose sensor is in contact with a patient;
storing the plurality of glucose sensor measurements as sensor data in a memory; and
detecting a decrease in an ability of the glucose sensor to accurately reflect a glucose level in a fluid of the patient based, at least in part, on an application of one or more thresholds to one or more sensitivity metrics, at least one of said sensitivity metrics being based, at least in part, on said glucose sensor measurements,
wherein at least one of the sensitivity metrics comprises a measurement of dispersion of a rate of change in the glucose sensor measurements over at least a portion of the time interval,
wherein a value of the measurement of dispersion that reflects a greater degree of dispersion corresponds to a greater ability of the glucose sensor to accurately reflect the glucose level, and a value of the measurement of dispersion that reflects a smaller degree of dispersion corresponds to a lesser ability of the glucose sensor to accurately reflect the glucose level, and
wherein the detecting the decrease in the ability of the glucose sensor, the application of the one or more thresholds to the one or more sensitivity metrics, and the measurement of dispersion of the rate of change in the glucose sensor measurements are performed by one or more processors.

2. The method of claim 1 , wherein said measurement of dispersion of said rate of change comprises a variance of said rate of change.

3. The method of claim 1 , wherein at least one of said sensitivity metrics comprises a computed mean value of said glucose sensor measurements obtained over said at least a portion of said time interval.

4. The method of claim 1 , and further comprising:
generating an alert signal in response to the detecting the decrease in the ability of the glucose sensor to accurately reflect a glucose level.

5. The method of claim 1 , wherein said at least a portion of said time interval comprises a sliding time window.

6. The method of claim 1 , wherein said one or more sensitivity metrics further comprise a mean value of said glucose sensor measurements over the at least a portion of said time interval, and wherein the decrease in the ability of the glucose sensor to accurately reflect the glucose level is detected if the measurement of dispersion of a rate of change in said glucose sensor measurements is less than a first threshold and the mean value of said glucose sensor measurements is less than a second threshold.

7. The method of claim 1 , wherein the fluid of the patient is an interstitial fluid.

8. A method comprising:
obtaining a plurality of glucose sensor measurements at a glucose sensor over a time interval by receiving an electrical current generated by the glucose sensor during a time that the glucose sensor is in contact with a patient;
storing the plurality of glucose sensor measurements as sensor data in a memory;
defining a sequence of windows in time;
for at least one of said windows, computing a dispersion of a rate of change in the glucose sensor measurements over at least one of the windows; and
detecting a decrease in an ability of the glucose sensor to accurately reflect a glucose level in a fluid of the patient, based, at least in part, on an application of one or more thresholds to the computed dispersion,
wherein a value of the computed dispersion that reflects a greater degree of dispersion corresponds to a greater ability of the glucose sensor to accurately reflect the glucose level, and a value of the computed dispersion that reflects a smaller degree of dispersion corresponds to a lesser ability of the glucose sensor to accurately reflect the glucose level, and
wherein the the detecting the decrease in the ability of the glucose sensor, the application of the one or more thresholds to the computed dispersion, and the computing of the dispersion of the rate of change in the glucose sensor measurements are performed by one or more processors.

9. The method of claim 8 , further comprising computing a mean value of the glucose sensor measurements in the at least one of the windows,
wherein the application of one or more thresholds to the computed dispersion comprises an application of the one or more thresholds to a ratio of said computed dispersion and the mean value.

10. An apparatus for use with a memory and with a patient having a fluid containing glucose, the apparatus comprising:
a glucose sensor configured to obtain glucose sensor measurements responsive to a presence of glucose in a fluid; and
a processor configured to:
store the plurality of glucose sensor measurements as sensor data in the memory; and
detect a decrease in an ability of the glucose sensor to accurately reflect a glucose level in the fluid of the patient based, at least in part, on an application of one or more thresholds to one or more sensitivity metrics, at least one of said sensitivity metrics being based, at least part, on said glucose sensor measurements,
wherein at least one of the sensitivity metrics comprises a measurement of dispersion of a rate of change in the glucose sensor measurements, and
wherein a value of the measurement of dispersion that reflects a greater degree of dispersion corresponds to a greater ability of the glucose sensor to accurately reflect the glucose level, and a value of the measurement of dispersion that reflects a smaller degree of dispersion corresponds to a lesser ability of the glucose sensor to accurately reflect the glucose level.

11. The apparatus of claim 10 , wherein said measurement of dispersion of said rate of change comprises a variance of said rate of change.

12. An apparatus for use with a memory and with a patient having a fluid containing glucose, the apparatus comprising:
a glucose sensor configured to obtain glucose sensor measurements responsive to a presence of glucose in a fluid; and
a processor configured to:
store the plurality of glucose sensor measurements as sensor data in the memory;
define a sequence of windows in time;
for at least one of said windows, compute a measure of dispersion of a rate of change in the glucose sensor measurements over at least one of the windows; and
detect a decrease in an ability of the glucose sensor to accurately reflect a glucose level in the fluid of the patient based, at least in part, on an application of one or more thresholds to the computed dispersion,
wherein a value of the computed dispersion that reflects a greater degree of dispersion corresponds to a greater ability of the glucose sensor to accurately reflect the glucose level, and a value of the computed dispersion that reflects a smaller degree of dispersion corresponds to a lesser ability of the glucose sensor to accurately reflect the glucose level.

13. An article for use with a glucose sensor, for use with a memory and for use with a patient having a fluid containing glucose, the article comprising:
a non-transitory storage medium having machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to:
initiate reception of a plurality of glucose sensor measurements from the glucose sensor over a time interval;
store the plurality of glucose sensor measurements as sensor data in the memory; and
detect a decrease in an ability of the glucose sensor to accurately reflect a glucose level in the fluid of the patient based, at least in part, on an application of one or more thresho

Assignees

• Medtronic Minimed Inc

Inventors

• Liang Bradley
• Cooper Kenneth W
• Gautham Raghavendhar
• Shah Rajiv

Classifications

• A61B5/1495 Primary

  Calibrating or testing of in-vivo probes · CPC title

• A61B5/14503

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence) · CPC title

• A61M2230/201

  Glucose concentration · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title