Determination and application of glucose sensor reliability indicator and/or metric

Patent metadata

Field	Value
Publication number	US-2017143276-A1
Application number	US-201715422329-A
Country	US
Kind code	A1
Filing date	Feb 1, 2017
Priority date	Oct 28, 2010
Publication date	May 25, 2017
Grant date	—

Abstract

Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

First claim

What is claimed is:

1 . A method comprising:
determining an indicator of reliability of an analyte sensor comprising a first pair of sensor elements of a first probe and a second pair of sensor elements of a second probe, wherein the indicator of reliability is based, at least in part, on a sensor integrity determination; and generating a sensor glucose signal and a sensor status signal based, at least in part, on the indicator of reliability.

2 . The method of claim 1 , wherein the sensor status signal comprises status signals for each sensor element of the first and second pairs of sensor elements.

3 . The method of claim 1 , wherein the sensor glucose signal is further based, at least in part, on signal values for each sensor element of the first and second pairs of sensor elements.

4 . The method of claim 3 , further comprising weighting the signal values for the first and second pairs of sensor elements.

5 . The method of claim 1 , wherein the sensor integrity determination is based, at least in part, on a trend metric or a noise metric, or a combination thereof.

6 . The method of claim 5 , wherein the trend metric is based, at least in part, on one or more detected non-physiological anomalies.

7 . The method of claim 5 , further comprising basing the sensor integrity determination on a voltage between two or more of the first and second pairs of sensor elements.

8 . The method of claim 5 , wherein the sensor integrity determination is also based, at least in part, on indications of past sensor behavior.

9 . The method of claim 1 , and further comprising transitioning a system from providing closed-loop continuous insulin infusion to a patient from an infusion pump to an open loop or manual operation based, at least in part, on the indicator of reliability.

10 . An apparatus comprising:
an analyte sensor to generate signals responsive to a concentration of an analyte in a fluid, the analyte sensor comprising two or more pairs of sensor elements including at least a first pair of sensor elements of a first probe and a second pair of sensor elements of a second probe; one or more processors to:
determine an indicator of reliability of the analyte sensor based, at least in part, on a sensor integrity determination; and
generate a sensor glucose signal and a sensor status signal based, at least in part, on the indicator of reliability.

11 . The apparatus of claim 10 , wherein the sensor status signal comprises status signals for each sensor element of the first and second pairs of sensor elements.

12 . The apparatus of claim 10 , wherein the sensor glucose signal is also based, at least in part, on signal values for each sensor element of the first and second pairs of sensor elements.

13 . The apparatus of claim 12 , wherein the one or more processors are further configured to weight the signal values for the first and second pairs of sensor elements.

14 . The apparatus of claim 10 , wherein the one or more processors are further configured to determine the sensor integrity based, at least in part, on a trend metric or a noise metric, or a combination thereof.

15 . The apparatus of claim 14 , wherein the trend metric is based, at least in part, on one or more detected non-physiological anomalies.

16 . The apparatus of claim 14 , wherein the one or more processors are further configured to determine the sensor integrity based, at least in part. on a voltage between two or more of the first and second pairs of sensor elements.

17 . The apparatus of claim 14 , wherein the one or more processors are further configured to determine the sensor integrity based, at least in part, on indications of past sensor behavior.

18 . The apparatus of claim 10 , and further comprising an infusion pump, and wherein the one or more processors are further configured to initiate transition of a system from providing closed-loop continuous insulin infusion to a patient from the infusion pump to an open loop or manual operation based, at least in part, on the indicator of reliability.

19 . An apparatus comprising:
means for determining an indicator of reliability of an analyte sensor comprising a first pair of sensor elements of a first probe and a second pair of sensor elements of a second probe, wherein the indicator of reliability is based, at least in part, on a sensor integrity determination; and means for generating a sensor glucose signal and a sensor status signal based, at least in part, on the indicator of reliability.

20 . The apparatus of claim 19 , and further comprising means for transitioning a system from providing closed-loop continuous insulin infusion to a patient from an infusion pump to an open loop or manual operation based, at least in part, on the indicator of reliability.

Assignees

• Medtronic Minimed Inc

Inventors

• Gottlieb Rebecca K
• Luo Ying
• Gautham Raghavendhar
• Liang Bradley
• Roy Anirban
• Cooper Kenneth W
• Shah Rajiv
• Keenan Barry

Classifications

• A61B5/6849

  in combination with a needle set · CPC title

• A61B5/4839

  combined with drug delivery · CPC title

• A61M5/1723

  using feedback of body parameters, e.g. blood-sugar, pressure (measurement of body parameters A61B5/00) · CPC title

• A61M2005/1726

  the body parameters being measured at, or proximate to, the infusion site · CPC title

• A61M2230/201

  Glucose concentration · CPC title