Systems and methods for treatment of fluid overload

Patent metadata

Field	Value
Publication number	US-10226604-B2
Application number	US-201815869907-A
Country	US
Kind code	B2
Filing date	Jan 12, 2018
Priority date	Nov 1, 2016
Publication date	Mar 12, 2019
Grant date	Mar 12, 2019

Abstract

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.

First claim

What is claimed is:

1. A device for treatment of edema, the device comprising:
an elongate member sized to fit within a body lumen;
an impeller operably coupled to the elongate member;
a restrictor proximal to the impeller, the restrictor having an opening there through;
a membrane forming a tapered conduit from the opening of the restrictor to the impeller; and
an outlet, wherein the device is configured such that a body fluid flows along an outside of the elongate member, through the opening in the restrictor and through the tapered conduit to the impeller.

2. The device of claim 1 , further comprising an impeller housing connected to a distal portion of the membrane, the impeller being disposed within the impeller housing.

3. The device of claim 2 , wherein the outlet is provided by one or more apertures along a side of the impeller housing.

4. The device of claim 2 , further comprising an atraumatic tip extending distally from the impeller housing.

5. The device of claim 1 , wherein the elongate member comprises a driveshaft for the impeller.

6. The device of claim 1 , wherein the elongate member is of a flexibility and stiffness to allow the impeller to be pushed into a lumen within a body.

7. The device of claim 6 , wherein the lumen is an innominate vein and the restrictor is dimensioned to occlude a jugular vein and a subclavian vein but for the opening therethrough.

8. The device of claim 1 , wherein the restrictor comprises an inflatable balloon.

9. The device of claim 1 , further comprising an introducer sheath through which the elongated member is slideably disposed.

10. The device of claim 9 , wherein the elongate member comprises a second restrictor disposed thereupon for delivery into, and inflation within, the jugular vein such that pressure between the restrictors is reduced while pressure cranially to the second restrictor is maintained.

11. A method for treating edema, the method comprising:
introducing an elongate member into a body lumen;
deploying a restrictor coupled at least in part to the elongate member by a membrane, to thereby form a tapered conduit through an opening through the restrictor and the membrane; and
operating an impeller to flow blood along an outside of the elongate member, through the opening in the restrictor and through the conduit to thereby reduce pressure near a lymphatic outflow duct.

12. The method of claim 11 , wherein a narrow end of the tapered conduit is coupled to an impeller housing having the impeller housed therein.

13. The method of claim 12 , wherein the blood flows out of the impeller housing via one or more apertures along a side of the impeller housing.

14. The method of claim 11 , wherein the blood flowing out of the tapered conduit results in reduced blood pressure proximally and cranially to the tapered conduit, while maintaining pressure distally towards the heart.

15. The method of claim 11 , wherein the body lumen is an innominate vein.

16. The method of claim 15 , wherein the restrictor occludes the innominate vein, or jugular and subclavian veins but for the opening therethrough.

17. The method of claim 11 , wherein introducing the elongate member into the body lumen includes pushing, by means of the elongate member, the restrictor towards a thoracic outflow duct.

18. The method of claim 17 , further comprising delivering the elongate member via a sheath that houses the elongated member and extends at least partially into the body lumen.

19. The method of claim 18 , further comprising deploying a second restrictor disposed along the elongate member.

20. The method of claim 11 , wherein the restrictor comprises an inflatable balloon and the method includes inflating the balloon to deploy the restrictor.

Assignees

• White Swell Medical Ltd

Inventors

• Nitzan Yaacov
• Raz Sagi
• Chen Shani
• Inbar Or

Classifications

• A61B5/4878 Primary

  Evaluating oedema · CPC title

• A61B5/02152

  specially adapted for venous pressure · CPC title

• A61B5/418

  lymph vessels, ducts or nodes · CPC title

• A61M2210/12

  Blood circulatory system · CPC title

• A61M2230/30

  Blood pressure (A61M2230/04 takes precedence) · CPC title