Pharmaceutical composition comprising thrombolytic peptide-tetrahydroisoquinoline conjugate
US-12059448-B2 · Aug 13, 2024 · US
US9533054B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9533054-B2 |
| Application number | US-201414203596-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 11, 2014 |
| Priority date | Mar 11, 2013 |
| Publication date | Jan 3, 2017 |
| Grant date | Jan 3, 2017 |
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The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.
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What is claimed is: 1. An amphiphilic compound having the structural formula: 2. An amphiphilic compound having the structural formula: 3. An amphiphilic compound having the structural formula: 4. An amphiphilic compound having the structural formula: 5. An amphiphilic compound having the structural formula:
Sugars, nucleosides, nucleotides or nucleic acids · CPC title
the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug · CPC title
the form being a nanoparticle, e.g. an immuno-nanoparticle · CPC title
having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid · CPC title
with ribosyl as the saccharide radical · CPC title
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