Use of substituted 2,3-dihydroimidazo[1,2-C]quinazolines

Patent metadata

Field	Value
Publication number	US-10202385-B2
Application number	US-201214009751-A
Country	US
Kind code	B2
Filing date	Mar 29, 2012
Priority date	Apr 5, 2011
Publication date	Feb 12, 2019
Grant date	Feb 12, 2019

Abstract

The present invention relates to: —use of a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or of a pharmaceutical composition containing same, as a sole active agent, or of a combination of a) said compound or a pharmaceutical composition containing said compound and b) one or more further active agents, for the preparation of a medicament for the treatment or prophylaxis of cancer; —combinations of a) said compound and b) one or more further active agents; —a pharmaceutical composition comprising said compound as a sole active agent for the treatment of breast cancer; —a pharmaceutical composition comprising a combination of a) said compound and b) one or more further active agents; —use of biomarkers involved in the modification of Bel expression, HER family expression and/or activation, PIK3CA signaling and/or loss of PTEN for predicting the sensitivity and/or resistance of a cancer patient to said compound and providing a rationale-based synergistic combination as defined herein to increase sensitivity and/or to overcome resistance; and —a method of determining the level of a component of one or more of Bcl expression, HER family expression and/or activation, PIK3CA signaling and/or loss of PTEN.

First claim

The invention claimed is:

1. A method for treatment of breast cancer comprising administering to a patient in need thereof a therapeutically effective amount of 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide, or a physiologically acceptable salt, solvate, hydrate, or stereoisomer thereof, wherein the breast cancer is inflammatory breast cancer, triple negative breast cancer, Her2 receptor positive breast cancer, or hormone receptor positive breast cancer.

2. The method according to claim 1 , comprising administering to the patient a therapeutically effective amount of:
2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide,
or a physiologically acceptable salt thereof.

3. The method according to claim 2 , wherein cells of the breast cancer do not express Bcl-2.

4. The method according to claim 2 , wherein the breast cancer is inflammatory breast cancer.

5. The method according to claim 2 , wherein the breast cancer is triple negative breast cancer.

6. The method according to claim 2 , wherein the breast cancer is Her2 receptor positive breast cancer.

7. The method according to claim 2 , wherein the breast cancer is hormone receptor positive breast cancer.

Assignees

• Liu Ningshu
• Schneider Claudia
• Bayer Ip Gmbh

Inventors

• Liu Ningshu
• Schneider Claudia

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P15/00

  Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives · CPC title

• G01N33/57515

  of the breast · CPC title

• C12Q1/6886

  for cancer (immunoassay for cancer G01N33/575) · CPC title