Modified ceramics with improved bioactivity and their use for bone substitute

Patent metadata

Field	Value
Publication number	US-10195306-B2
Application number	US-201615380227-A
Country	US
Kind code	B2
Filing date	Dec 15, 2016
Priority date	Dec 15, 2015
Publication date	Feb 5, 2019
Grant date	Feb 5, 2019

Abstract

The present invention concerns ceramics having a modified surface with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.

First claim

The invention claimed is:

1. A process for modifying a macroporous calcium phosphate ceramic comprising:
hydroxyapatite (HA), or
tricalcium phosphate (TCP), or
a mixture thereof in the form of biphasic calcium phosphate (BCP), said process comprising:

reacting said ceramic with supercritical CO 2 in the presence of an aqueous solution.

2. The process according to claim 1 wherein the aqueous solution comprises one or more organic solvents.

3. The process according to claim 1 , wherein the quantity of the solution is such that the weight solution/ceramic ratio (L/S ratio) is comprised between 0.5 and 50.

4. The process according to claim 1 , wherein the reaction is carried out at a pressure comprised between 2 and 10000 bar and a temperature comprised between 20 and 400° C.

5. The process according to claim 1 , wherein the reaction is carried out at a pressure comprised between 60 and 150 bar and a temperature comprised between 30 and 50° C.

6. The process according to claim 1 wherein the reaction mixture is maintained at an acid pH.

Assignees

• Univ Toulouse 3 Paul Sabatier
• Centre Nat Rech Scient

Inventors

• Cazalbou Sophie

Classifications

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L2430/12

  for dental implants or prostheses · CPC title

• C04B41/85

  with inorganic materials · CPC title

• C01B25/327

  After-treatment · CPC title

• A61L2430/24

  for joint reconstruction · CPC title