Electrical stimulation devices and related methods
US-9833615-B2 · Dec 5, 2017 · US
US9107976B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107976-B2 |
| Application number | US-201113702852-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 10, 2011 |
| Priority date | Nov 17, 2010 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.
Opening claim text (preview).
The invention claimed is: 1. A method of adhesion between bone and cartilage, comprising: applying a composition comprising a surface-modified hydroxyapatite as an active ingredient to provide adhesion between said bone and cartilage, with the proviso that the composition does not include chitosan, wherein the surface-modified hydroxyapatite is modified such that there is an aldehyde group on the surface of the surface-modified hydroxyapatite and wherein the hydroxyapatite is…
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