Core-shell nanoparticles with multiple cores and method for fabricating them

Patent metadata

Field	Value
Publication number	US-10191042-B2
Application number	US-201815960115-A
Country	US
Kind code	B2
Filing date	Apr 23, 2018
Priority date	Feb 20, 2007
Publication date	Jan 29, 2019
Grant date	Jan 29, 2019

Abstract

The present invention is directed toward core-shell nanoparticles, each comprising a ligand-capped metal shell surrounding a plurality of discrete, nonconcentric, metal-containing cores. Methods of making and using these nanoparticles are also disclosed.

First claim

What is claimed:

1. Core-shell nanoparticles, each core-shell nanoparticle comprising:
a shell containing a gold-silver mixture;
a plurality of discrete, nonconcentric, cores containing an iron-cobalt mixture, each core being within and surrounded by said shell; and
a ligand cap over said shell.

2. The core-shell nanoparticles according to claim 1 , wherein the nanoparticles are present in a monodispersion with controlled diameters ranging from 5 nm to 100 nm.

3. The core-shell nanoparticles according to claim 1 , wherein the iron in the core is an iron oxide which is magnetic, paramagnetic, or superparamagnetic.

4. The core-shell nanoparticles according to claim 1 , wherein the iron in the core is an iron oxide-containing core comprising a compound selected from the group consisting of Fe 3 O 4 and Fe 2 O 3 .

5. The core-shell nanoparticles according to claim 4 , wherein the iron in the core is an iron oxide-containing core comprising Fe 2 O 3 .

6. The core-shell nanoparticles according to claim 1 , wherein the ligand cap is selected from the group consisting of decanethiolate, oleylamine, oleic acid, acrylates, N,N-trimethyl(undecylmercapto)ammonium (TUA), tetrabutylammonium tetrafluoroborate (TBA), tetramethylammonium bromide (TMA), cetyltrimethylammonium bromide (CTAB), citrates, poly methacrylate, ascorbic acid, DNA, 2-mercaptopropionic acid (MPA), 3-mercaptopropionic acid (MPA), 11-mercaptoundecanoic acid (MUA), 10-mercaptodecane-1-sulfonic acid, 16-mercaptohexadecanoic acid, diimide, N-(2-mercaptopropionyl)glycine (tiopronin), 2-mercaptoethanol, 4-mercapto-1-butanol, dodecyl sulfate, amino acids, homocysteine, homocystine, cysteine, cystine, glutathione, mercaptobenzoic acid (MBA), Protein A, bovine serum albumin (BSA), and anti-rabbit-IgG (Ab).

7. The core-shell nanoparticles according to claim 6 , wherein the ligand cap is selected from the group consisting of decanethiolate, oleylamine, and oleic acid.

8. The core-shell nanoparticles according to claim 7 , wherein the ligand cap is decanethiolate.

9. The core-shell nanoparticles according to claim 7 , wherein the ligand cap is oleylamine.

10. The core-shell nanoparticles according to claim 7 , wherein the ligand cap is oleic acid.

11. The core-shell nanoparticles according to claim 1 further comprising:
a first binding material bound to the ligand-capped shell.

12. The core-shell nanoparticles according to claim 11 , wherein the first binding material is selected from the group consisting of proteins, peptides, antibodies, and antigens.

Assignees

• Univ New York State Res Found

Inventors

• Zhong Chuan-Jian
• Park Hye-Young

Classifications

• G01N33/54346 Primary

  Nanoparticles · CPC title

• G01N33/54353

  with ligand attached to the carrier via a chemical coupling agent (coatings G01N33/54393) · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• G01N33/553

  Metal or metal coated · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title