Core-shell nanoparticles with multiple cores and a method for fabricating them

Patent metadata

Field	Value
Publication number	US-9327314-B2
Application number	US-201213680749-A
Country	US
Kind code	B2
Filing date	Nov 19, 2012
Priority date	Feb 20, 2007
Publication date	May 3, 2016
Grant date	May 3, 2016

Abstract

The present invention is directed toward core-shell nanoparticles, each comprising a ligand-capped metal shell surrounding a plurality of discrete, nonconcentric, metal-containing cores. Methods of making and using these nanoparticles are also disclosed.

First claim

What is claimed:

1. A method of producing core-shell nanoparticles, each comprising a ligand-capped metal shell surrounding a plurality of discrete metal-containing cores, said method comprising:
providing ligand-capped metal-containing core material nanoparticles;
providing ligand-capped metal shell material nanoparticles; and
reacting the ligand-capped metal-containing core material nanoparticles and the ligand-capped metal shell material nanoparticles to produce the core-shell nanoparticles comprising a ligand-capped metal shell surrounding a plurality of discrete metal-containing cores, wherein said reacting comprises:
combining the ligand-capped metal-containing core material nanoparticles and the ligand-capped metal shell material nanoparticles in a solvent to form a reaction mixture and
heating the reaction mixture to form the core-shell nanoparticles comprising a ligand-capped metal shell surrounding the plurality of metal-containing cores, wherein said heating raises the temperature of the reaction mixture to a temperature of 140-160° C.

2. The method according to claim 1 wherein the core-shell nanoparticles are present in a monodispersion with controlled diameters ranging from 5 nm to 100 nm.

3. The method according to claim 1 , wherein the solvent is selected from the group consisting of toluene, tetraoctylammonium bromide, and decanethiols.

4. The method according to claim 1 , wherein said reacting further comprises:
subjecting the core-shell nanoparticles to at least one sizing operation.

5. The method according to claim 4 , wherein the sizing operation comprises centrifugation.

6. The method according to claim 1 , wherein the ligand-capped metal containing core material nanoparticles are ligand-capped Fe 2 O 3 nanoparticles.

7. The method according to claim 6 , wherein the capping ligand of the ligand-capped Fe 2 O 3 nanoparticles is selected from the group consisting of oleylamine and oleic acid.

8. The method according to claim 1 , wherein the ligand-capped shell material nanoparticles are decanethiolate capped gold nanoparticles.

9. The method according to claim 1 , wherein the core material nanoparticles are magnetic, paramagnetic, or superparamagnetic.

10. The method according to claim 1 , wherein the metal of the core material nanoparticles is selected from the group consisting of iron, magnesium, cobalt, and mixtures thereof.

11. The method according to claim 10 , wherein the metal of the core material nanoparticles is iron.

12. The method according to claim 11 , wherein the core of the core material nanoparticles comprises an iron-oxygen compound selected from the group consisting of Fe 3 O 4 and Fe 2 O 3 .

13. The method according to claim 12 , wherein the core of the core material nanoparticles comprises Fe 2 O 3 .

14. The method according to claim 1 , wherein the metal of the metal shell material nanoparticles is selected from the group consisting of gold, silver, platinum, rhodium, palladium, vanadium, titanium, iron, cobalt, magnesium, ruthenium, chromium, molybdenum, tantalum, zirconium, manganese, tin, and mixtures thereof.

15. The method according to claim 14 , wherein the metal of the metal shell material nanoparticles is gold.

16. The method according to claim 1 , wherein the metal shell material nanoparticles and the metal-containing core material nanoparticles are independently capped with a capping ligand selected from the group consisting of decanethiolate, oleylamine, oleic acid, acrylates, N,N-trimethyl(undecylmercapto)ammonium (TUA), tetrabutylammonium tetrafluoroborate (TBA), tetramethylammonium bromide (TMA), cetyltrimethylammonium bromide (CTAB), citrates, poly methacrylate, ascorbic acid, DNA, 2-mercaptopropionic acid (MPA), 3-mercaptopropionic acid (MPA), 11-mercaptoundecanoic acid (MUA), 10-mercaptodecane-1-sulfonic acid, 16-mercaptohexadecanoic acid, diimide, N-(2-mercaptopropionyl)glycine (tiopronin), 2-mercaptoethanol, 4-mercapto-1-butanol, dodecyl sulfate, amino acids, homocysteine, homocystine, cysteine, cystine, glutathione, mercaptobenzoic acid (MBA), Protein A, bovine serum albumin (BSA), and anti-rabbit-IgG (Ab).

17. The method according to claim 16 , wherein the capping ligand is selected from the group consisting of decanethiolate, oleylamine, and oleic acid.

18. The method according to claim 17 , wherein the capping ligand is decanethiolate.

19. The method according to claim 17 , wherein the capping ligand is oleylamine.

20. The method according to claim 17 , wherein the capping ligand is oleic acid.

21. The method according to claim 1 , wherein the core-shell nanoparticles each comprises a ligand-capped metal shell surrounding a plurality of discrete, non-concentric metal-containing cores.

Assignees

• Univ New York State Res Found
• Univ New York State Res Found

Inventors

• Zhong Chuan-Jian
• Park Hye-Young

Classifications

• B05D7/00 Primary

  Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials {(coating of foodstuffs A23P20/17, A23P20/15, A23P20/18)} · CPC title

• B01J13/02 Primary

  Making microcapsules or microballoons {(for medical preparations A61K9/50)} · CPC title

• G01N33/54353

  with ligand attached to the carrier via a chemical coupling agent (coatings G01N33/54393) · CPC title

• G01N33/553

  Metal or metal coated · CPC title

• B03C1/30

  Combinations with other devices, not otherwise provided for · CPC title