Cyan-excitable orange-red fluorescent proteins and bioluminescent resonance energy transfer systems
US-2016376332-A1 · Dec 29, 2016 · US
Dual-modality imaging probe for combined localization and apoptosis detection of stem cells
US10188752B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10188752-B2 |
| Application number | US-201715669634-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 4, 2017 |
| Priority date | Aug 4, 2016 |
| Publication date | Jan 29, 2019 |
| Grant date | Jan 29, 2019 |
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Abstract
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A ferumoxytol-based dual-modality imaging probe for long-term stem cell tracking through MRI and early diagnosis of cell apoptosis through simultaneous fluorescence imaging is provided. Specifically, a ferumoxytol-based dual-modality imaging probe is provided with enhanced T 2 * relaxivity for tracking stem cells through magnetic resonance imaging and detecting apoptotic stem cells through fluorescence imaging.
First claim
Opening claim text (preview).
What is claimed is: 1. A dual-modality imaging probe for simultaneous, one-stop, cell apoptosis detection and stem cell tracking, comprising: ferumoxytol with a fluorescent signature peptide immobilized on the surface of the ferumoxytol, wherein the fluorescent signature peptide is a KKKKDEVD-AFC peptide (SEQ ID NO:1).
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Classifications
characterised by the carrier · CPC title
- A61K49/0045Primary
the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo · CPC title
Peptides, proteins, polyamino acids · CPC title
- A61K49/0039Primary
Coumarin dyes · CPC title
Peptides, e.g. proteins · CPC title
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- What does patent US10188752B2 cover?
- A ferumoxytol-based dual-modality imaging probe for long-term stem cell tracking through MRI and early diagnosis of cell apoptosis through simultaneous fluorescence imaging is provided. Specifically, a ferumoxytol-based dual-modality imaging probe is provided with enhanced T 2 * relaxivity for tracking stem cells through magnetic resonance imaging and detecting apoptotic stem cells through fluo…
- Who is the assignee on this patent?
- Univ Leland Stanford Junior
- What technology area does this patent fall under?
- Primary CPC classification A61K49/0045. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).