Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders
US-9822102-B2 · Nov 21, 2017 · US
Substituted oxopyridine derivatives and use thereof cardiovascular disorders
US10183932B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10183932-B2 |
| Application number | US-201715786352-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 17, 2017 |
| Priority date | Mar 28, 2013 |
| Publication date | Jan 22, 2019 |
| Grant date | Jan 22, 2019 |
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Abstract
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The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for the treatment and/or prevention of disseminated intravascular coagulation (DIC) comprising administering a therapeutically effective amount of a compound ({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-[tetrahydro-2H-pyran-2-yl]propanoyl}amino)benzoic acid of the formula: or a salt thereof, solvate thereof or solvates of a salt thereof, to a human or animal in need thereof. 2. A method according to claim 1 , wherein the compound is a stereoisomer of the compound with formula wherein the stereoisomer has a formula: 3. A method for the treatment and/or prevention of sepsis comprising administering a therapeutically effective amount of the compound ({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-[tetrahydro-2H-pyran-2-yl]propanoyl}amino)benzoic acid of the formula: or a salt thereof, solvate thereof or solvates of a salt thereof, to a human or animal in need thereof. 4. A method according to claim 3 , wherein the compound is a stereoisomer of the compound with formula wherein the stereoisomer has a formula: 5. A method for the treatment and/or prevention of disseminated intravascular coagulation (DIC) comprising administering a therapeutically effective amount of the compound ({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-[tetrahydro-2H-pyran-2-yl]propanoyl}amino)benzoic acid of the formula: 6. A method according to claim 5 , wherein the compound is a stereoisomer of the compound with formula wherein the stereoisomer has a formula: 7. A method for the treatment and/or prevention of sepsis comprising administering a therapeutically effective amount of the compound ({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-[tetrahydro-2H-pyran-2-yl]propanoyl}amino)benzoic acid of the formula: 8. A method according to claim 7 , wherein the compound is a stereoisomer of the compound with formula wherein the stereoisomer has a formula:
Assignees
Inventors
Classifications
Drugs for disorders of the cardiovascular system · CPC title
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title
Drugs for disorders of the blood or the extracellular fluid · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Ophthalmic agents · CPC title
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Frequently asked questions
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- What does patent US10183932B2 cover?
- The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
- Who is the assignee on this patent?
- Bayer Pharma AG
- What technology area does this patent fall under?
- Primary CPC classification C07D405/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).