Process and composition for killing spores
US-2015305342-A1 · Oct 29, 2015 · US
US10183087B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10183087-B2 |
| Application number | US-201514936775-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 10, 2015 |
| Priority date | Nov 10, 2015 |
| Publication date | Jan 22, 2019 |
| Grant date | Jan 22, 2019 |
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The disclosed invention relates to a two-part liquid composition for cleaning and disinfecting a substrate, comprising: (A) a disinfectant medium comprising peracetic acid; and (B) a supplemental medium comprising a non-enzymatic cleaner, a corrosion inhibitor, and a chelator. The supplemental medium (B) may further comprise an enzymatic cleaner, a surfactant, a buffer, a pH modifier, or a mixture of two or more thereof. The substrate may be a medical device, for example, an endoscope.
Opening claim text (preview).
The invention claimed is: 1. A two-part liquid composition for cleaning and disinfecting a substrate contaminated with living microorganisms, comprising: (A) a disinfectant medium comprising water; peracetic acid, acetic acid, hydrogen peroxide and sulfuric acid, wherein the concentration of peracetic acid in the disinfectant medium (A) is from about 5 to about 60% by weight, the concentration of sulfuric acid in the disinfectant medium (A) is from about 0.5% to about 2% by weight, and the pH of the disinfectant medium (A) being from about 1 to about 8; and (B) a supplemental medium comprising water, an enzymatic cleaner, a non-enzymatic cleaner, a corrosion inhibitor, a surfactant and a chelator; wherein the enzymatic cleaner comprises a protein digesting enzyme; and wherein the non-enzymatic cleaner comprises an alkanol amine, a polyalkylene glycol, an alkyl diproprionate, an alkyl dialkylamine oxide, or a mixture of two or more thereof, wherein the concentration of the enzymatic cleaner in (B) is from about 0.2 to about 25% by weight, the concentration of the non-enzymatic cleaner in (B) is from about 0.1 to about 25% by weight, the concentration of the corrosion inhibitor in (B) is from about 1% to about 10% by weight, the concentration of the surfactant in (B) is from about 1 to about 25% by weight, the concentration of the chelator in (B) is from about 0.1 to about 70%, the pH of the supplemental medium (B) is from about 6 to about 14, and the volumetric ratio of (A) to (B) is in the range from about 5:1 to 1:5. 2. The composition of claim 1 wherein the disinfectant medium (A) comprises from about 15% to about 45% by weight of peracetic acid. 3. The composition of claim 1 wherein supplemental medium (B) further comprises a buffer, a pH modifier or a mixture thereof. 4. The composition of claim 1 wherein the alkanol amine comprises monoethanol amine, diethanol amine, triethanol amine, or a mixture of two or more thereof. 5. The composition of claim 1 wherein the alkyl diproprionate comprises an octyl diproprionate. 6. The composition of claim 1 wherein the alkyl dialkylamine oxide comprises octyl dimethylamine oxide. 7. The composition of claim 1 wherein the supplemental medium (B) comprises monoethanolamine, triethanolamine, octyldimethylamine oxide, a polyalkylene glycol, octyl dipropionate, or a mixture of two or more thereof. 8. The composition of claim 1 wherein the supplemental medium (B) comprises from about 1 to about 25% by weight of the non-enzymatic cleaner. 9. The composition of claim 1 wherein the supplemental medium (B) comprises from about 0.5 to about 10% by weight of the enzymatic cleaner. 10. The composition of claim 3 wherein the buffer comprises an alkali metal phosphate, an alkali metal carbonate, or a mixture thereof. 11. The composition of claim 3 wherein the supplemental medium (B) comprises up to about 15% by weight of the buffer. 12. The composition of claim 1 wherein the supplemental medium (B) comprises from about 1% to about 5% by weight of the corrosion inhibitor. 13. The composition of claim 1 wherein the supplemental medium (B) comprises from about 0.3 to about 60% by weight of the chelator. 14. The composition of claim 1 wherein the surfactant comprises a detergent, wetting agent, emulsifier, foaming agent and/or dispersant. 15. The composition of claim 1 wherein the surfactant comprises a compound that contains at least one hydrophobic group and at least one hydrophilic group. 16. The composition of claim 1 wherein the surfactant comprises a water insoluble component and a water soluble component. 17. The composition of claim 1 wherein the surfactant comprises an anionic, cationic, zwitterionic and/or nonionic compound. 18. The composition of claim 1 wherein the surfactant comprises one or more polyalkylene glycol ethers, alkylarylsulfonates, amine oxides, poly(oxyalkylene) compounds, block copolymers comprising alkylene oxide repeat units, carboxylated alcohol ethoxylates, ethoxylated alkyl phenols, ethoxylated amines, ethoxylated amides, oxiranes, ethoxylated fatty acids, ethoxylated fatty esters, ethoxylated oils, fatty esters, fatty acid amides, glycerol esters, glycol esters, sorbitan esters, imidazoline and/or derivatives thereof, lecithin and/or derivatives thereof, lignin and/or derivatives thereof, glycerides and/or derivatives thereof, olefin sulfonates, phosphate esters and/or derivatives thereof, propoxylated and/or ethoxylated fatty acids and/or alcohols, alkyl phenols, sorbitan and/or derivatives thereof, sucrose esters and/or derivatives thereof, sulfates and/or alcohols and/or ethoxylated alcohols of fatty esters, sulfonates of dodecyl and/or tridecyl benzenes, condensed naphthalenes, sulfosuccinates and/or derivatives thereof, tridecyl and/or dodecyl benzene sulfonic acids, octyl betaine, or a mixture of two or more thereof. 19. The composition of claim 1 wherein the concentration of the surfactant in the supplemental medium (B) is in the range from about 5 to about 15% by weight. 20. The composition of claim 1 wherein part the supplemental medium (B) further comprises one or more scale inhibitors, preservatives, defloculents, suspension agents, metal passivators, thickening agents, antifoam agents, foam enhancing agents, oil removal agents, sequestration agents, rheology modification agents, penetration agents, solubility agents, rinse aids, or a mixture of two or more thereof. 21. The composition of claim 1 wherein the supplemental medium (B) has a pH in the range from about 6 to about 9. 22. The composition of claim 1 wherein the volumetric ratio of (A) to (B) is from about 4:1 to about 1:4. 23. The composition of claim 1 wherein the disinfectant medium (A) is diluted with water, the volumetric ratio of water to the disinfectant medium (A) being up to about 1000:1. 24. The composition of claim 1 wherein the supplemental medium (B) is diluted with water, the volumetric ratio of water to the supplemental medium (B) being up to about 1000:1. 25. A process for cleaning and disinfecting a substrate using the two-part liquid composition of claim 1 , comprising: (1) contacting the substrate with the supplemental medium (B) to clean the substrate, and (2) contacting the substrate with the disinfectant medium (A) to disinfect the substrate. 26. A process for cleaning and disinfecting a substrate using the two-part liquid composition of claim 1 , comprising: (1) contacting the substrate with the supplemental medium (B) and the disinfectant medium (A) to clean the substrate, and (2) contacting the substrate with the disinfectant medium (A) to disinfect the substrate. 27. A process for cleaning and disinfecting a substrate using the two-part liquid composition of claim 1 , comprising: (1) contacting the substrate with the supplemental medium (B) to clean the substrate, and (2) contacting the substrate with the disinfectant medium (A) and the supplemental medium (B) to disinfect the substrate. 28. A process for cleaning and disinfecting a substrate using the two-part liquid composition of claim 1 , comprising: (1) contacting the substrate with the supplemental medium (B) and the disinfectant (A) to clean the substrate, and (2) contacting the substrate with the disinfectant medium (A) and the supplemental medium (B) to disinfect the substrate. 29. The process of clai
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