Core-shell nanoparticles comprising same element of different isotopes
US-9835628-B2 · Dec 5, 2017 · US
US10174136B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10174136-B2 |
| Application number | US-201715445020-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 28, 2017 |
| Priority date | Feb 29, 2016 |
| Publication date | Jan 8, 2019 |
| Grant date | Jan 8, 2019 |
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Methods for making a plurality of nanoparticles are provided. The method may include flowing a first component of the core into a reaction chamber; flowing a polymeric material into the reaction chamber; and flowing a second component of the core into the reaction chamber such that the first component reacts with the second component to form a core. The polymeric material forms a polymeric shell around the core.
Opening claim text (preview).
What is claimed: 1. A method of making a plurality of nanoparticles via a continuous flow-through process, the method comprising: continuously flowing a first component of a core and a polymeric material into a reaction chamber, wherein the first component of the core and the polymeric material are first dissolved in water free of organic solvents, wherein the polymeric material is polyvinylpyrrolidone; and continuously flowing a second component of the core into the reaction chamber such that the first component reacts with the second component to form a core, wherein the polymeric material forms a polymeric shell around the core, wherein the reaction chamber has a temperature of about 60° C. to about 120° C. when the polymeric material, the first component of the core, and the second component of the core are supplied into the reaction chamber. 2. The method of claim 1 , wherein the reaction chamber has a temperature of about 80° C. to about 100° C. 3. The method of claim 1 , wherein the first component is a metal salt. 4. The method of claim 3 , wherein the metal salt comprises an iron chloride. 5. The method of claim 4 , wherein the iron chloride comprises FeCl 2 , FeCl 3 , or a mixture thereof. 6. The method of claim 3 , wherein the second component is an oxygen source. 7. The method of claim 6 , wherein the oxygen source comprises ammonium hydroxide. 8. The method of claim 6 , wherein the core comprises a metal oxide. 9. The method of claim 8 , wherein the metal oxide comprises iron oxide, silica, alumina, indium tin oxide, titania, or a mixture thereof. 10. The method of claim 1 , wherein the core precipitates from the water after reaction of the first component and the second component. 11. The method as in claim 1 , wherein the polyvinylpyrrolidone has a molecular mass of about 10 kDa to about 360 kDa. 12. The method as in claim 1 , wherein the core is magnetic. 13. The method as in claim 1 , wherein the core has an average size that about 100 nm or less. 14. The method as in claim 1 , wherein the core has an average size of about 15 nm to about 50 nm.
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