Method for producing purified low-substituted hydroxypropyl cellulose

Patent metadata

Field	Value
Publication number	US-10174128-B2
Application number	US-201314079704-A
Country	US
Kind code	B2
Filing date	Nov 14, 2013
Priority date	Nov 16, 2012
Publication date	Jan 8, 2019
Grant date	Jan 8, 2019

Abstract

Provided is a method for producing low-substituted hydroxypropyl cellulose with less yellowing. More specifically, the method for producing purified low-substituted hydroxypropyl cellulose includes the steps of: reacting alkali cellulose and an etherifying agent to obtain a reaction mixture; dispersing the reaction mixture in water containing a portion of acetic acid necessary for neutralizing the total amount of the reaction mixture to neutralize a portion of the reaction mixture, and then completely neutralizing with the remaining acetic acid to cause precipitation, to obtain a slurry containing crude low-substituted hydroxypropyl cellulose; disintegrating a solid component in the slurry through a cutter pump, the solid component containing the crude low-substituted hydroxypropyl cellulose, and discharging the slurry containing the disintegrated solid component; washing the discharged slurry with water to obtain a cake of purified low-substituted hydroxypropyl cellulose; and drying the cake.

First claim

The invention claimed is:

1. A method for producing purified low-substituted hydroxypropyl cellulose, comprising the steps of:
reacting alkali cellulose and an etherifying agent to obtain a reaction mixture;
dispersing the reaction mixture in water containing a first portion of acid to neutralize a portion of the reaction mixture, thereby causing partial precipitation, and then completely neutralizing a remaining portion of the reaction mixture with a second portion of the acid to cause precipitation, to obtain a slurry containing crude low-substituted hydroxypropyl cellulose;
disintegrating a solid component in the slurry through a cutter pump, the solid component containing the crude low-substituted hydroxypropyl cellulose, and discharging the slurry containing the disintegrated solid component, said disintegrated solid component having an average particle size of from 1.0 to 2.4 mm, and wherein the solid component containing the crude low-substituted hydroxypropyl cellulose in the slurry to be fed to the cutter pump has an average particle size of from 2.5 to 6.0 mm;
washing the discharged slurry with water to obtain a cake of purified low-substituted hydroxypropyl cellulose; and
drying the cake.

2. The method for producing purified low-substituted hydroxypropyl cellulose according to claim 1 , wherein the step of disintegrating further comprises disintegrating the slurry, fed from a slurry tank for storing the slurry containing the crude low-substituted hydroxypropyl cellulose, through the cutter pump, and discharging the slurry containing the disintegrated solid component or returning the slurry to the slurry tank for circulation, wherein an average particle size of the disintegrated low-substituted hydroxypropyl cellulose to be discharged is regulated by controlling the disintegrating frequency through the cutter pump by providing a cutter pump bypass flow passage which enables the slurry to go around the cutter pump.

3. The method for producing purified low-substituted hydroxypropyl cellulose according to claim 2 , wherein passage of the slurry through the cutter pump bypass flow passage is driven by a rotary pump provided between the slurry tank and the cutter pump and/or between the cutter pump and a branch point at which the slurry is introduced into a washing machine to be used in the step of washing or the slurry is returned to the slurry tank for circulation.

4. The method for producing purified low-substituted hydroxypropyl cellulose according to claim 3 , wherein the rotary pump is provided between the cutter pump and the branch point, and the solid component in the slurry to be fed to the rotary pump after passing through the cutter pump has an average particle size of from 1.5 to 2.4 mm.

5. The method for producing a purified low-substituted hydroxypropyl cellulose according to claim 3 , wherein the average particle size of the disintegrated low-substituted hydroxypropyl cellulose to be discharged is regulated by providing a rotary pump bypass flow passage which enables the slurry to go around the rotary pump and thereby controlling the treatment frequency through the rotary pump.

Assignees

• Shinetsu Chemical Co

Inventors

• Kitamura Akira
• Yonemochi Atsuhiko
• Narita Mitsuo

Classifications

• C08B11/08 Primary

  with hydroxylated hydrocarbon radicals; Esters, ethers, or acetals thereof · CPC title

• B01J20/041

  Oxides or hydroxides · CPC title

• C08B1/08 Primary

  Alkali cellulose · CPC title