Modulators of toll-like receptors

Patent metadata

Field	Value
Publication number	US-10172860-B2
Application number	US-201715659526-A
Country	US
Kind code	B2
Filing date	Jul 25, 2017
Priority date	Dec 9, 2008
Publication date	Jan 8, 2019
Grant date	Jan 8, 2019

Abstract

Provided are modulators of TLRs of Formula II:

pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

First claim

We claim:

1. A compound of the Formula:

or a pharmaceutically acceptable salt thereof, wherein:
L 1 is —O—, —S—, —S(O) 2 —, or —S(O)—;
R 1 is alkyl;
X 1 is alkylene;
D is phenyl;
L 2 is alkylene;
n is 0;
R 4 and R 5 are each independently H; and
R 6 and R 7 , taken together with the nitrogen to which they are both attached, form an unsubstituted 4-6 membered heterocycle, which may contain one or more additional heteroatoms selected from N, O, or S.

2. The compound of claim 1 , wherein L 1 is —O—.

3. The compound of claim 1 , wherein X 1 is —CH 2 —.

4. The compound of claim 1 , wherein L 2 is —CH 2 —.

5. The compound of claim 1 , selected from the group consisting of:

or a salt thereof.

6. The compound of claim 1 , selected from the group consisting of:

or a salt thereof.

7. The compound of claim 1 , selected from the group consisting of:

or a salt thereof.

8. The compound of claim 1 , selected from the group consisting of:

or a salt thereof.

9. The compound of claim 1 , having the structure:

or a salt thereof.

Assignees

• Gilead Sciences Inc

Inventors

• Desai Manoj C
• Halcomb Randall L
• Hrvatin Paul
• Hui Hon Chung
• Mcfadden Ryan
• Roethle Paul A
• Yang Hong

Classifications

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P31/12

  Antivirals · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P31/18

  for HIV · CPC title

• A61P31/20

  for DNA viruses · CPC title