Porous surface for biomedical devices

Patent metadata

Field	Value
Publication number	US-10167574-B2
Application number	US-201414577971-A
Country	US
Kind code	B2
Filing date	Dec 19, 2014
Priority date	Oct 31, 2014
Publication date	Jan 1, 2019
Grant date	Jan 1, 2019

Abstract

Embodiments described herein generally relate to biomedical devices including a porous layer forming a support structure for a biological probe and methods of making the same. The porous layer can be a porous silicon containing layer. The pore size can be adjusted such that various size biological probes can be incorporated into the pores. Further, the porous silicon containing layer can be used to support a biofunctionalizing layer.

First claim

What is claimed is:

1. A biomedical device, comprising:
a support structure, the support structure comprising:
a substrate; and
one or more layers on the substrate, the support structure being transmissive to at least one wavelength of radiation;

a microarray formation layer formed over the support structure, wherein the microarray formation layer is a silicon nitride layer, and the microarray formation layer has one or more wells formed therein, each of the one or more wells having a bottom surface;
a porous silicon-containing layer formed on the bottom surface of the one or more wells, the porous silicon-containing layer having an exposed surface; and
a biological probe positioned in connection with the exposed surface of the porous silicon-containing layer.

2. The biomedical device of claim 1 , further comprising a biofunctionalizing material positioned on the exposed surface of the porous silicon-containing layer.

3. The biomedical device of claim 2 , wherein the biofunctionalizing material is a hydrogel.

4. The biomedical device of claim 1 , wherein the one or more layers comprise:
a dielectric layer formed on the first surface;
a color filter layer formed on the dielectric layer;
a second dielectric layer formed on the color filter layer; and
a metal containing layer formed on the second dielectric layer.

5. The biomedical device of claim 4 , wherein the metal containing layer comprises TaN.

6. The biomedical device of claim 1 , wherein the porous silicon-containing layer is doped with boron, nitrogen, carbon, helium or combinations thereof.

7. The biomedical device of claim 1 , wherein the porous silicon-containing layer is transparent to at least one wavelength of radiation which is shared with the one or more layers.

8. The biomedical device of claim 1 , wherein the porous silicon-containing layer is a doped silicon oxide layer.

9. The biomedical device of claim 1 , wherein the biological probe is a polynucleotide.

10. A biomedical device, comprising:
a support structure, the support structure comprising:
a substrate having a first surface;
a dielectric layer formed on the first surface;
a color filter layer formed on the dielectric layer;
a second dielectric layer formed on the color filter layer; and
a metal containing layer formed on the second dielectric layer;

a microarray formation layer formed over the metal containing layer, the microarray formation layer having one or more wells formed therein, each of the one or more wells having a bottom surface in contact with the metal containing layer;
a porous silicon-containing layer formed on the bottom surface of the one or more wells, the porous silicon-containing layer having an exposed surface; and
a biofunctionalizing material formed on the porous surface.

11. The biomedical device of claim 10 , wherein the biofunctionalizing material is a hydrogel.

12. The biomedical device of claim 10 , wherein the porous silicon-containing layer is doped with boron, nitrogen, carbon, helium or combinations thereof.

13. A biomedical device, comprising:
a metal containing layer formed over a support substrate, wherein the metal containing layer comprises tantalum oxide layer, a tungsten oxide layer, or a hafnium oxide layer;
a microarray formation layer formed over the metal containing layer, the microarray formation layer having one or more wells formed through the microarray formation layer to expose a portion of the metal containing layer;
a porous silicon-containing layer formed on the exposed portion of the metal containing layer in the one or more wells;
a biofunctionalizing material formed over the porous silicon-containing layer; and
a biological probe positioned over the biofunctionalizing material and in connection with the porous silicon-containing layer.

14. The biomedical device of claim 13 , wherein the porous silicon-containing material comprises silicon and oxygen.

15. The biomedical device of claim 14 , wherein the porous silicon-containing layer is doped with boron, nitrogen, carbon, helium or combinations thereof.

16. The biomedical device of claim 13 , wherein the biofunctionalizing material is a hydrogel.

17. The biomedical device of claim 13 , wherein the biological probe is a polynucleotide.

18. A biomedical device, comprising:
a metal containing layer formed over a support substrate, wherein the metal containing layer comprises tantalum oxide layer, a tungsten oxide layer, or a hafnium oxide layer;
a microarray formation layer formed over the metal containing layer, wherein the microarray formation layer is a silicon nitride layer, and the microarray formation layer has one or more wells formed through the microarray formation layer to expose a portion of the metal containing layer;
a porous silicon-containing layer formed on the exposed portion of the metal containing layer in the one or more wells;
a biofunctionalizing material formed over the porous silicon-containing layer; and
a biological probe positioned over the biofunctionalizing material and in connection with the porous silicon-containing layer.

Assignees

• Applied Materials Inc

Inventors

• Jeong Sangmin
• Chao Hann-Ching
• Godet Ludovic

Classifications

• B01J2219/00722

  Nucleotides · CPC title

• B01L3/5085

  for multiple samples, e.g. microtitration plates · CPC title

• B01J19/0046

  Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays (synthesis methods per se C40B50/00) · CPC title

• C40B50/18

  using a particular method of attachment to the solid support · CPC title

• B01L2200/12

  Specific details about manufacturing devices · CPC title