Hemostatic compositions and methods of making and using same

Patent metadata

Field	Value
Publication number	US-10149926-B2
Application number	US-201514873630-A
Country	US
Kind code	B2
Filing date	Oct 2, 2015
Priority date	Aug 31, 2010
Publication date	Dec 11, 2018
Grant date	Dec 11, 2018

Abstract

The disclosure pertains to hemostatic compositions comprising a plurality of nonwoven fibers disposed in a rapidly soluble solid matrix and methods of making and using the same. The compositions may also comprise one or more therapeutic agents.

First claim

What is claimed:

1. A method of sealing a tissue puncture comprising:
providing a hemostatic composition comprising:
a plurality of nonwoven fibers;
a rapidly soluble solid matrix,
wherein the fibers are embedded within the rapidly soluble solid matrix such that the space occupied by the fibers is free of voids; and
one or more therapeutic agents;

inserting the hemostatic composition into a tissue puncture;
exposing the hemostatic composition to at least one of a body fluid or saline;
liquefying the rapidly soluble solid matrix upon contact with the at least one of a body fluid or saline and releasing the plurality of nonwoven fibers; and
allowing the plurality of nonwoven fibers to swell upon contact with the at least one of a body fluid or saline, thereby occluding the tissue puncture.

2. The method of claim 1 , wherein the plurality of nonwoven fibers are greater than about 50 nanometers in diameter and less than about 20 microns in diameter.

3. The method of claim 1 , wherein the plurality of nonwoven fibers comprise a non-cellulosic polysaccharide.

4. The method of claim 1 , wherein the liquefying step releases at least a portion of the one or more therapeutic agents.

5. The method of claim 1 , wherein the rapidly soluble solid matrix comprises a sugar.

6. The method of claim 1 , wherein the rapidly soluble solid matrix consists of a sugar.

7. The method of claim 1 , wherein the rapidly soluble solid matrix comprises water ice.

8. The method of claim 1 , wherein the rapidly soluble solid matrix consists of water ice.

9. The method of claim 1 , wherein the material of the plurality of nonwoven fibers includes crosslinks.

10. The method of claim 1 , wherein the material of the plurality of nonwoven fibers swells upon contact with at least one of a body fluid or saline.

Assignees

• Boston Scient Scimed Inc
• Boston Scient Scimed Inc

Inventors

• Schewe Scott
• Warner Robert
• Weber Jan
• Arney Michael

Classifications

• A61K9/70

  Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} · CPC title

• A61L31/125 Primary

  having a macromolecular matrix · CPC title

• A61B17/0057 Primary

  Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009) · CPC title

• A61L2300/41

  Anti-inflammatory agents, e.g. NSAIDs · CPC title

• A61B2017/00654

  entirely comprised between the two sides of the opening · CPC title