Template-fixed peptidomimetics
US-9879047-B2 · Jan 30, 2018 · US
Template-fixed peptidomimetics
US10144765B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10144765-B2 |
| Application number | US-201715851270-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 21, 2017 |
| Priority date | Feb 28, 2007 |
| Publication date | Dec 4, 2018 |
| Grant date | Dec 4, 2018 |
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Abstract
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The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
First claim
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The invention claimed is: 1. A method for treating cancer that expresses a CXCR4 receptor, the method comprising: administering a therapeutically effective amount of a Cyclo(-Tyr-His-X-Cys-Ser-Ala- D Pro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys- D Pro-Pro) compound having a disulfide bond between Cys4 and Cys11, or a pharmaceutically acceptable salt thereof, wherein X is Ala to a subject in need thereof. 2. The method of claim 1 , wherein the administering is oral, topical, transdermal, injection, buccal, transmucosal, pulmonary or inhalation administration. 3. The method of claim 1 , wherein the compound is administered in a composition further comprising a pharmaceutically inert carrier and wherein the composition is in the form of a tablet, a dragee, a capsule, a solution, a liquid, a gel, a plaster, a cream, an ointment, a syrup, a slurry, a suspension, a spray, a nebulizer, or a suppository. 4. The method of claim 1 , wherein the cancer is breast cancer.
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Frequently asked questions
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- What does patent US10144765B2 cover?
- The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
- Who is the assignee on this patent?
- Univ Zuerich, Polyphor Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07K7/56. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 04 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 9 related publications on this page (citations in our corpus or others sharing the same primary CPC).