Template-fixed peptidomimetics with antimicrobial activity
US-9596852-B2 · Mar 21, 2017 · US
Template-fixed peptidomimetics
US9879047B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9879047-B2 |
| Application number | US-201615379820-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 15, 2016 |
| Priority date | Feb 28, 2007 |
| Publication date | Jan 30, 2018 |
| Grant date | Jan 30, 2018 |
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- Title
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Abstract
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The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala- D Pro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys- D -Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for treating cancer that expresses a CXCR4 receptor, the method comprising: administering a therapeutically effective amount of a Cyclo(-Tyr-His-X-Cys-Ser-Ala- D Pro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys- D Pro-Pro) compound having a disulfide bond between Cys4 and Cysl1, or a pharmaceutically acceptable salt thereof, wherein X is Ala or Tyr to a subject in need thereof. 2. The method of claim 1 , wherein the administering is oral, topical, transdermal, injection, buccal, transmucosal, pulmonary or inhalation administration. 3. The method of claim 1 , wherein the compound is administered in a composition further comprising a pharmaceutically inert carrier and wherein the composition is in the form of a tablet, a dragee, a capsule, a solution, a liquid, a gel, a plaster, a cream, an ointment, a syrup, a slurry, a suspension, a spray, a nebulizer, or a suppository. 4. The method of claim 1 , wherein the cancer is breast cancer.
Assignees
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Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Immunosuppressants, e.g. drugs for graft rejection · CPC title
Antineoplastic agents · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Antivirals · CPC title
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- What does patent US9879047B2 cover?
- The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala- D Pro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys- D -Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
- Who is the assignee on this patent?
- Univ Zuerich, Polyphor Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07K7/56. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 30 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).