Subchondral treatment of joint pain of the spine

Patent metadata

Field	Value
Publication number	US-10130484-B2
Application number	US-201815947026-A
Country	US
Kind code	B2
Filing date	Apr 6, 2018
Priority date	Aug 7, 2011
Publication date	Nov 20, 2018
Grant date	Nov 20, 2018

Abstract

Methods for altering the natural history of degenerative disc disease and osteoarthritis of the spine are proposed. The methods focus on the prevention, or delayed onset or progression of, subchondral defects such as bone marrow edema or bone marrow lesion, and subchondral treatment to prevent the progression of osteoarthritis or degenerative disc disease in the spine and thereby treat pain.

First claim

What is claimed is:

1. A method of injecting an injectable fluid material into a targeted treatment area in a subchondral region of a vertebral body of a patient for inhibiting progression of a bone marrow lesion (BML) identified in the subchondral region, the method comprising:
identifying a bone marrow lesion in a subchondral region of a vertebral body of a patient, the vertebral body including a superior cartilaginous endplate abutting a first intervertebral disc and an inferior cartilaginous endplate abutting a second intervertebral disc;
creating, in the vertebral body that contains the bone marrow lesion in the subchondral region, a subchondral injection path to a targeted treatment area for injecting an injectable fluid material into the targeted treatment area, wherein the targeted treatment area includes an area in the subchondral region where the bone marrow lesion was identified, wherein said creating is conducted without creating a void in the targeted treatment area that opens into the superior cartilaginous endplate of the vertebral body or into the inferior cartilaginous endplate of the vertebral body so as to preserve an existing condition of the superior cartilaginous endplate of the vertebral body and an existing condition of the inferior cartilaginous endplate of the vertebral body; and
injecting an injectable fluid material into the targeted treatment area via the subchondral injection path so that at least some of the injectable fluid material is introduced into defective bone that remains in the identified bone marrow lesion following said creating for becoming less fluid in the defective bone for reinforcing the defective bone, wherein the injectable fluid material includes an osteogenic, osteoconductive and/or osteoinductive material, wherein the injectable fluid material is left in the targeted treatment area without also delivering and leaving a solid structural implant in the targeted treatment area in addition to the injectable fluid material.

2. The method of claim 1 , wherein said identifying includes identifying with MRI.

3. The method of claim 1 , wherein the injectable fluid material includes bone marrow.

4. The method of claim 1 , wherein the injectable fluid material includes a calcium phosphate.

5. The method of claim 1 , wherein said creating is performed percutaneously.

6. The method of claim 1 , wherein the subchondral injection path is created with a needle.

7. A method of injecting an injectable fluid material into a targeted treatment area in a subchondral region of a vertebral body of a patient for inhibiting progression of a bone marrow lesion (BML) identified in the subchondral region, the method comprising:
identifying a bone marrow lesion in a subchondral region of a vertebral body of a patient so as to establish an identified bone marrow lesion, the vertebral body including a superior cartilaginous endplate abutting a first intervertebral disc and an inferior cartilaginous endplate abutting a second intervertebral disc;
targeting a treatment area in the subchondral region of the vertebral body so as to establish a targeted treatment area for receiving treatment, wherein the targeted treatment area includes an area in the identified bone marrow lesion;
creating, in the vertebral body that contains the bone marrow lesion in the subchondral region, a subchondral injection path to the targeted treatment area for injecting an injectable fluid material into the targeted treatment area, wherein said creating is conducted without creating a void in the targeted treatment area that opens into the superior cartilaginous endplate of the vertebral body or into the inferior cartilaginous endplate of the vertebral body so as to preserve an existing condition of the superior cartilaginous endplate of the vertebral body and an existing condition of the inferior cartilaginous endplate of the vertebral body; and
injecting an injectable fluid material into the targeted treatment area via the subchondral injection path so that at least some of the injectable fluid material is introduced into defective bone that remains in the identified bone marrow lesion following said creating for becoming less fluid in the defective bone for reinforcing the defective bone, wherein the injectable fluid material is left in the targeted treatment area without also delivering and leaving a solid structural implant in the targeted treatment area in addition to the injectable fluid material, and wherein the injectable fluid material includes an osteogenic, osteoconductive and/or osteoinductive material.

8. The method of claim 7 , wherein said identifying includes identifying with MRI.

9. The method of claim 7 , wherein the targeted treatment area is in the identified bone marrow lesion.

10. The method of claim 7 , wherein the targeted treatment area is in and adjacent to the identified bone marrow lesion.

11. The method of claim 7 , wherein the injectable fluid material includes bone marrow.

12. The method of claim 7 , wherein the injectable fluid material includes a calcium phosphate.

13. The method of claim 7 , wherein said creating is performed percutaneously.

14. The method of claim 7 , wherein the subchondral injection path is created with a needle.

Assignees

• Zimmer Knee Creations Inc

Inventors

• Sharkey Peter F
• Leinberry Charles F
• Nichols David L
• Viscogliosi Marc R
• Mathews Hallett

Classifications

• A61F2002/30011

  differing in porosity · CPC title

• A61F2002/30032

  differing in absorbability or resorbability, i.e. in absorption or resorption time · CPC title

• A61F2002/30451

  soldered or brazed or welded · CPC title

• A61F2/3094

  Designing or manufacturing processes · CPC title

• A61F2310/00928

  Coating or prosthesis-covering structure made of glass or of glass-containing compounds, e.g. of bioglass · CPC title