Subchondral treatment of joint pain of the spine

Patent metadata

Field	Value
Publication number	US-9402670-B2
Application number	US-201514862887-A
Country	US
Kind code	B2
Filing date	Sep 23, 2015
Priority date	Aug 7, 2011
Publication date	Aug 2, 2016
Grant date	Aug 2, 2016

Abstract

Methods for altering the natural history of degenerative disc disease and osteoarthritis of the spine are proposed. The methods focus on the prevention, or delayed onset or progression of, subchondral defects such as bone marrow edema or bone marrow lesion, and subchondral treatment to prevent the progression of osteoarthritis or degenerative disc disease in the spine and thereby treat pain.

First claim

What is claimed is:

1. A method of reinforcing bone located in a targeted bone marrow lesion (BML) in a subchondral region of a vertebral body for treating the targeted bone marrow lesion, the method comprising:
identifying a bone marrow lesion in a subchondral region of a vertebral body so as to establish a targeted bone marrow lesion for receiving treatment, the vertebral body including a superior vertebral endplate with a superior articular surface and an inferior vertebral endplate with an inferior articular surface, wherein said identifying includes identifying with MRI;
creating, in the vertebral body that contains the targeted bone marrow lesion in the subchondral region, a subchondral injection path to an area in and/or adjacent to the targeted bone marrow lesion for injecting an injectable bone filling material into said area for reinforcing bone located in the targeted bone marrow lesion, wherein said creating preserves an existing condition of the superior articular surface of the vertebral body and an existing condition of the inferior articular surface of the vertebral body; and
injecting an injectable and curable bone filling material into said area via the subchondral injection path, wherein the injectable bone filling material is a bone reinforcing material that is left in the area for hardening in the area so as to form, in situ, a bone reinforcing member for reinforcing bone located in the targeted bone marrow lesion, wherein the injectable bone filling material is left in the area without also delivering and leaving a structural implant device in and/or adjacent to the targeted bone marrow lesion in addition to the injectable bone filling material.

2. The method of claim 1 , wherein said creating is conducted without further creating a void in or adjacent to the targeted bone marrow lesion.

3. The method of claim 1 , wherein the injectable bone filling material envelopes the targeted bone marrow lesion.

4. The method of claim 1 , wherein said creating is performed percutaneously.

5. The method of claim 1 , wherein said creating is performed arthroscopically.

6. The method of claim 1 , wherein the subchondral region occurs in a facet.

7. The method of claim 1 , wherein the subchondral injection path is created with a needle.

8. The method of claim 1 , wherein said area is in the targeted bone marrow lesion.

9. A method of reinforcing bone located in a targeted bone marrow lesion (BML) in a subchondral region of a vertebral body for treating the targeted bone marrow lesion, the method comprising:
identifying a bone marrow lesion in a subchondral region of a vertebral body so as to establish a targeted bone marrow lesion for receiving treatment, the vertebral body including a superior vertebral endplate with a superior articular surface and an inferior vertebral endplate with an inferior articular surface, wherein said identifying includes identifying with MRI;
creating, in the vertebral body that contains the targeted bone marrow lesion in the subchondral region, a subchondral injection path to an area in and/or adjacent to the targeted bone marrow lesion for injecting an injectable bone filling material into said area for reinforcing bone located in the targeted bone marrow lesion, wherein said creating preserves an existing condition of the superior articular surface of the vertebral body and an existing condition of the inferior articular surface of the vertebral body; and
injecting an injectable and curable bone filling material into said area via the subchondral injection path, wherein the injectable bone filling material is a bone reinforcing material that is left in the area for hardening in the area so as to form, in situ, a bone reinforcing member for reinforcing bone located in the targeted bone marrow lesion, wherein the injectable bone filling material envelopes the targeted bone marrow lesion, and wherein the injectable bone filling material is left in the area without also delivering and leaving a structural implant device in and/or adjacent to the targeted bone marrow lesion in addition to the injectable bone filling material.

10. The method of claim 9 , wherein said creating is conducted without further creating a void in or adjacent to the targeted bone marrow lesion.

11. The method of claim 9 , wherein said creating is performed percutaneously.

12. The method of claim 9 , wherein said creating is performed arthroscopically.

13. The method of claim 9 , wherein the subchondral region occurs in a facet.

14. The method of claim 9 , wherein the subchondral injection path is created with a needle.

15. The method of claim 9 , wherein said area is in the targeted bone marrow lesion.

16. A method of reinforcing bone located in a targeted bone marrow lesion (BML) in a subchondral region of a vertebral body for treating the targeted bone marrow lesion, the method comprising:
identifying a bone marrow lesion in a subchondral region of a vertebral body so as to establish a targeted bone marrow lesion for receiving treatment, the vertebral body including a superior vertebral endplate with a superior articular surface and an inferior vertebral endplate with an inferior articular surface, wherein said identifying includes identifying with MRI;
creating, in the vertebral body that contains the targeted bone marrow lesion in the subchondral region, a subchondral injection path to an area in and/or adjacent to the targeted bone marrow lesion for injecting an injectable bone filling material into said area for reinforcing bone located in the targeted bone marrow lesion, wherein said creating preserves an existing condition of the superior articular surface of the vertebral body and an existing condition of the inferior articular surface of the vertebral body, and is conducted without further creating a void in or adjacent to the targeted bone marrow lesion; and
injecting an injectable and curable bone filling material into said area via the subchondral injection path, wherein the injectable bone filling material is a bone reinforcing material that is left in the area for hardening in the area so as to form, in situ, a bone reinforcing member for reinforcing bone located in the targeted bone marrow lesion, wherein the injectable bone filling material envelopes the targeted bone marrow lesion.

17. The method of claim 16 , wherein the subchondral region occurs in a facet.

18. The method of claim 16 , wherein said area is in the targeted bone marrow lesion.

19. The method of claim 16 , wherein said creating is performed percutaneously.

20. The method of claim 16 , wherein the subchondral injection path is created with a needle.

Assignees

• Zimmer Knee Creations Inc

Inventors

• Sharkey Peter F
• Leinberry Charles F
• Nichols David L
• Viscogliosi Marc R
• Mathews Hallett

Classifications

• A61F2/3094

  Designing or manufacturing processes · CPC title

• A61F2002/30011

  differing in porosity · CPC title

• A61F2002/30032

  differing in absorbability or resorbability, i.e. in absorption or resorption time · CPC title

• A61F2002/30451

  soldered or brazed or welded · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title