Quantification of inter-ocular suppression in binocular vision impairment

Patent metadata

Field	Value
Publication number	US-10123693-B2
Application number	US-201515312376-A
Country	US
Kind code	B2
Filing date	Jul 17, 2015
Priority date	May 20, 2014
Publication date	Nov 13, 2018
Grant date	Nov 13, 2018

Abstract

Systems, apparatus, and methods are provided for quantifying inter-ocular suppression in binocular vision impairment. The systems, apparatus, and methods may include a stimulus presentation device and a controller which present different stimuli to each eye of a patient. The stimuli can include letters, numbers, or shapes which are arranged in rows, and columns with a stimulus presented to each eye in a location corresponding a stimulus presented to the other eye. The combined contrast of corresponding stimuli equals a predetermined value, and this contrast can be adjusted with each iteration of stimuli presented. This adjustment can be based upon the patient's reports of what is seen and adjustments made by an algorithm executed by the controller. Suppression can thus be determined in terms of visual field location and quantified.

First claim

What is claimed is:

1. A system for quantifying suppression in binocular vision of a patient, the system comprising:
a stimuli presentation device configured to present stimuli comprising a distinct stimulus for each eye of the patient, the distinct stimulus including a first stimulus for a right eye and a second stimulus for a left eye; and
a controller, operably connected to the stimuli presentation device, the controller comprising:
a computer comprising an interface configured to accept input from a clinician, a patient, or both,
an adaptive algorithm executed on the computer, the adaptive algorithm configured to accept a report describing what the patient sees when presented with the stimuli and calculate adjustments to the stimuli to be presented in a next iteration of stimuli, and
a stimulus generating component configured to provide the next iteration of stimuli to the patient via the stimuli presentation device,

wherein the first stimulus for the right eye includes a first feature and a second feature, the first feature including a first contrast value, the second feature including a second contrast value;
wherein the second stimulus for the left eye includes a third feature and a fourth feature, the third feature corresponding to the first feature and including a third contrast value, the fourth feature corresponding to the second feature and including a fourth contrast value;
wherein a sum of the first contrast value and the third contrast value equals a fixed amount;
wherein a sum of the second contrast value and the fourth contrast value equals the fixed amount.

2. The system of claim 1 , wherein the stimuli presentation device comprises 3D stereo shutter glasses, anaglyph glasses, polarized lenses, a Wheatstone stereogram, head mounted displays, and/or lenticular screens.

3. The system of claim 1 , wherein the system is configured to measure scale dependent suppression in the binocular vision of the patient.

4. The system of claim 3 , wherein the stimuli comprise bandpass filtered Sloan letters laid out in a manner comprising multiple rows of letters, each row of decreasing letter size, and each row having multiple letter, wherein each letter in a row is distinct and having a different amount of contrast.

5. The system of claim 4 , wherein each distinct stimulus for each eye of the patient has the same number of rows of letters and columns of letters, wherein a letter on a right eye stimulus corresponds to a letter on a left eye stimulus in a similar position, further wherein the corresponding letters have a combined contrast that is the fixed amount.

6. The system of claim 3 , wherein the Sloan letters of the stimuli comprise peak spatial-frequencies of 0.5 to 10 cycles per degree.

7. The system of claim 3 , wherein the Sloan letters create a pattern that covers a main area of a contrast sensitivity function.

8. The system of claim 1 , wherein the system is configured to measure suppression in the binocular vision of the patient while each eye of the patient is fixated on a spot on the distinct stimulus presented to each eye.

9. The system of claim 1 , wherein the system is configured to measure both visual-field and spatial-frequency dependent suppression in the binocular vision of the patient.

10. The system of claim 1 , wherein the stimuli comprise numbers or colored dots.

11. The system of claim 1 , wherein the stimulus generating component comprises program code executed on the computer.

12. A method comprising:
presenting, via a computer controller and a stimuli presentation device, stimuli to a patient, the stimuli comprising a distinct stimulus for each eye of the patient, the distinct stimulus including a first stimulus for a right eye and a second stimulus for a left eye;
accepting, via the computer controller, reports comprising observations from the patient regarding the stimuli;
creating an adjusted stimuli via an adaptive algorithm executed on the computer controller, the adaptive algorithm using the reports as input; and
presenting to the patient the adjusted stimuli via a stimulus generating component of the computer controller and the stimuli presentation device;
wherein the first stimulus for the right eye includes a first feature and a second feature, the first feature including a first contrast value, the second feature including a second contrast value;
wherein the second stimulus for the left eye includes a third feature and a fourth feature, the third feature corresponding to the first feature and including a third contrast value, the fourth feature corresponding to the second feature and including a fourth contrast value;
wherein a sum of the first contrast value and the third contrast value equals a fixed amount;
wherein a sum of the second contrast value and the fourth contrast value equals the fixed amount.

13. The method of claim 12 , further comprising evaluating the reports to determine whether suppression in binocular vision of the patient can be quantified.

14. The method of claim 12 , further comprising quantifying suppression in binocular vision of the patient.

15. The method of claim 12 , wherein the stimuli comprise bandpass filtered Sloan letters, numbers, or colored dots.

16. The method of claim 15 , wherein the first feature, the second feature, the third feature and the fourth feature comprise the bandpass filtered Sloan letters, numbers, or colored dots.

17. The method of claim 16 , wherein the first stimulus and the second stimulus further comprise additional corresponding features, each additional feature has a contrast value, further wherein a sum of the additional contrast values for corresponding additional features equals the fixed amount, the fixed amount being the same for each pair of corresponding features.

18. The method of claim 12 , wherein the stimulus generating component comprises program code executed on the computer controller.

19. The method of claim 12 , wherein the stimuli presentation device comprises 3D stereo shutter glasses, anaglyph glasses, polarized lenses, a Wheatstone stereogram, head mounted displays, and/or lenticular screens.

20. A non-transitory computer-readable medium encoded with instructions that, when executed by at least one processor, cause operations comprising:
presenting, via a computer controller and a stimuli presentation device, stimuli to a patient, the stimuli comprising a distinct stimulus for each eye of the patient, the distinct stimulus including a first stimulus for a right eye and a second stimulus for a left eye;
accepting, via the computer controller, reports comprising observations from the patient regarding the stimuli;
creating an adjusted stimuli via an adaptive algorithm executed on the computer controller, the adaptive algorithm using the reports as input; and
presenting to the patient the adjusted stimuli via a stimulus generating component of the computer controller and the stimuli presentation device;
wherein the first stimulus for the right eye includes a first feature and a second feature, the first feature including a first contrast value, the second feature including a second contrast value;
wherein the second stimulus for the left eye includes a third feature and a fourth feature, the third feature corresponding to the first feature and including a third contrast value, the fourth feature corresponding to the second feature and including a fourth contrast value;
wherein a sum of the first contrast value and the third contrast value equals a fixed amount;
wherein a sum o

Assignees

• Schepens Eye Res Inst

Inventors

• Bex Peter
• Dakin Steven
• KWON Miyoung
• Wiecek Emily

Classifications

• G02B2027/014

  comprising information/image processing systems · CPC title

• G02B2027/0112

  comprising device for genereting colour display · CPC title

• G02B2027/011

  comprising device for correcting geometrical aberrations, distortion · CPC title

• G02B2027/0134

  of stereoscopic type · CPC title

• G02B2027/0178

  Eyeglass type (eyeglass details G02C) · CPC title