Compositions relating to vitamin D

Patent metadata

Field	Value
Publication number	US-10106498-B2
Application number	US-201515319206-A
Country	US
Kind code	B2
Filing date	Jun 22, 2015
Priority date	Jun 27, 2014
Publication date	Oct 23, 2018
Grant date	Oct 23, 2018

Abstract

This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R 1 ) p -(L) q -Z wherein R 1 , L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.

First claim

What is claimed is:

1. A composition comprising one or more of a compound of the formula:
NHR 1′ —(CH 2 ) r′ —NR 1″ —((CH 2 ) r′ —NR 1′″ ) s′ —(CH 2 ) r′ —NR 7′ —Z′ wherein

R 1′ , R 1″ or R 1′″ are each independently selected from

 and H,
wherein at least one of R 1′ , R 1″ or R 1′″ is not H,
n is an integer from 1 to 10,
r′ is independently an integer from 1 to 10,
s′ is an integer from 1 to 10,
R 7′ is H or alkyl,
R 11′ is H, alkyl, or acyl, and
Z′ is a poly(amino acid) immunogenic carrier, a non-poly(amino acid) immunogenic carrier, a poly(amino acid) label moiety, a non-poly(amino acid) label moiety, a non-label poly(amino acid) moiety, or a non-immunogenic carrier poly(amino acid) moiety.

2. The composition according to claim 1 wherein s′ of the compound is 1.

3. The composition according to claim 1 wherein R 7′ of the compound is H.

4. The composition according to claim 1 wherein r′ of the compound is 2.

5. The composition according to claim 1 wherein R 1′ of the compound is

and
R 1″ and R 1′″ of the compound are H.

6. The composition according to claim 1 wherein R 1′ and R 1″ of the compound are

and
R 1′″ of the compound is H.

7. The composition according to claim 1 wherein R 1′ , R 1″ and R 1′″ of the compound are

8. The composition according to claim 1 wherein Z′ of the compound is a poly(amino acid) immunogenic carrier selected from the group consisting of bovine serum albumin, bovine gamma globulin, keyhole limpet hemocyanin, and egg ovalbumin.

9. The composition according to claim 1 wherein the poly(amino acid) label of the compound is an enzyme.

10. The composition according to claim 1 wherein the non-poly (amino acid) label of the compound is selected from the group consisting of (a) polynucleotides coding for a catalyst, (b) promoters, (c) dyes, (d) fluorescent molecules, (e) chemiluminescent molecules, (f)coenzymes, (g) enzyme substrates, (h) radioactive groups, (i) small organic molecules, and (j) amplifiable polynucleotide sequences.

11. The composition of claim 1 wherein the non-poly(amino acid) label moiety is associated with a support.

12. The composition of claim 11 wherein the support is a particle.

Assignees

• Siemens Healthcare Diagnostics Inc

Inventors

• Teng Zhu
• Liao Qimu
• Sharma Manoj
• Drinan Martin A
• Wei Tie Quan

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• C07C2601/14

  The ring being saturated · CPC title

• A61K31/59

  Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems · CPC title

• G01N33/82

  involving vitamins {or their receptors} · CPC title

• C07C401/00 Primary

  Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation · CPC title