Compositions and methods for detecting vitamin D

Patent metadata

Field	Value
Publication number	US-9244083-B2
Application number	US-201213690332-A
Country	US
Kind code	B2
Filing date	Nov 30, 2012
Priority date	Nov 30, 2012
Publication date	Jan 26, 2016
Grant date	Jan 26, 2016

Abstract

Compounds include carbamate derivatives of vitamin D including vitamin D 3 and vitamin D 2 . The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.

First claim

What is claimed is:

1. A compound of the formula:

wherein:
Z is an alkyl, alkenyl or alkynyl group having 1 to 10 carbon atoms, which may be unsubstituted or one or more of which may be substituted by one or more of hydroxy, lower alkoxy, oxo, and oxime;
R is —O-succinimidyl; and
R 4 is H, OH or lower alkoxy.

2. The compound according to claim 1 wherein Z is a branched alkyl group or a branched alkenyl group having 4 to 10 carbon atoms wherein a terminal carbon atom of the branched alkyl group or the branched alkenyl group comprises a hydroxyl.

3. A compound of the formula:

or a compound of the formula:

wherein:
R′ is —O-succinimidyl;
R l is H, OH, or protected OH; and
R 4 is H, OH or lower alkoxy.

Assignees

• Teng Zhu
• Janzen Roland
• Drinan Martin A
• Siemens Healthcare Diagnostics

Inventors

• Teng Zhu
• Janzen Roland
• Drinan Martin A

Classifications

• C07C401/00 Primary

  Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation · CPC title

• A61K39/385

  Haptens or antigens, bound to carriers · CPC title

• C07C2601/14

  The ring being saturated · CPC title

• Y10T436/203332

  Hydroxyl containing · CPC title

• G01N33/82 Primary

  involving vitamins {or their receptors} · CPC title