Sensing platform for transduction of information

Patent metadata

Field	Value
Publication number	US-10101293-B2
Application number	US-201414455205-A
Country	US
Kind code	B2
Filing date	Aug 8, 2014
Priority date	Aug 9, 2013
Publication date	Oct 16, 2018
Grant date	Oct 16, 2018

Abstract

Aspects of a biosensor platform system and method are described. In one embodiment, the biosensor platform system includes a fluidic system and tunneling biosensor interface coupled to the fluidic system. The tunneling biosensor interface may include a transducing electrode array having at least one dielectric thin film deposited on an electrode array. The biosensor platform system may further include processing logic operatively coupled to the transducing electrode array. In operation, the application of an electromagnetic field at an interface between an electrode and an electrolyte in the system, for example, may result in the transfer of charge across the interface. The transfer of charge is, in turn, characterized by electromagnetic field-mediated tunneling of electrons that may be assisted by exchange of energy with thermal vibrations at the interface. By analysis of the transfer of charge, the identify of various analytes, for example, or other compositions.

First claim

At least the following is claimed:

1. A biosensor platform system, comprising:
a tunneling biosensor interface configured to operatively couple to a fluidic system configured to receive a sample comprising a redox specie and an analyte specie, the tunneling biosensor interface comprising:
a transducing electrode array comprising at least one dielectric thin film deposited on an electrode array and configured to contact the sample, wherein the at least one dielectric thin film comprises a sequential layering of low-k and high-k dielectric materials; and
processing logic operatively coupled to the transducing electrode array, and configured to apply a voltage bias between the received sample and the transducing electrode array, the applied voltage bias configured to generate a tunneling current configured to flow from the redox specie to the transducing electrode array via the at least one dielectric thin film,

wherein the tunneling current is indicative of the analyte specie.

2. The biosensor platform system of claim 1 , wherein the fluidic system comprises at least one of:
a sample acquisition zone;
a filtration module in fluidic communication with the sample acquisition zone;
an immunoseparation module in fluidic communication with the filtration module;
a tapered micro-chromatogram in fluidic communication with the immunoseparation module; and
an adsorption pad in fluidic communication with the tapered micro-chromatogram.

3. The biosensor platform system of claim 1 , wherein the at least one dielectric thin film comprises a sequential layering of low-k and high-k dielectric substacks interspersed with thin films of a non-magnetic dielectric insulator.

4. The biosensor platform system of claim 1 , wherein the processing logic includes a low noise transimpedance amplifier configured to detect the tunneling current.

5. The biosensor platform system of claim 1 , wherein the tunneling current is indicative of molecular vibrational states of the analyte specie located at the biosensor interface.

6. A biosensor platform system, comprising:
a fluidic system configured to receive a sample comprising a redox specie and an analyte specie;
a biosensor interface including dielectric thin films layered on an electrode array on a semiconductor die, wherein the dielectric thin films comprise tunneling barriers at metal-dielectric and dielectric-electrolyte interfaces; and
processing logic operatively coupled to the biosensor interface, and configured to apply a voltage bias between the received sample and an electrode in the electrode array, the applied voltage bias configured to generate a tunneling current configured to flow from the redox specie to the electrode array via the dielectric thin films,
wherein the tunneling current is indicative of the analyte specie.

7. The biosensor platform system of claim 6 , wherein the processing logic is coupled to the electrode array by through-silicon vias in the semiconductor die.

8. The biosensor platform system of claim 6 , wherein the fluidic system comprises at least one of:
a sample acquisition zone;
a filtration module in fluidic communication with the sample acquisition zone;
an immunoseparation module in fluidic communication with the filtration module;
a tapered micro-chromatogram in fluidic communication with the immunoseparation module; and
an adsorption pad in fluidic communication with the tapered micro-chromatogram.

9. The biosensor platform system of claim 6 , wherein the processing logic comprises a voltage source to apply the voltage bias, and the applied voltage bias is further configured to produce a weakly-coupled non-adiabatic electron flux across a transducing electrode array of the biosensor interface.

10. The biosensor platform system of claim 6 , wherein the dielectric thin films comprise a sequential layering of low-k and high-k dielectric materials.

11. The biosensor platform system of claim 10 , wherein the high-k dielectric materials comprise at least one a material selected from the group consisting of:
Ta 2 O 2 ;
ZrO 2 , and
TiO 2 .

12. The biosensor platform system of claim 10 , wherein the low-k dielectric materials comprise one of HfO2 and SiO2.

13. The biosensor platform system of claim 6 , wherein the dielectric thin films comprise a sequential layering of low-k and high-k dielectric substacks interspersed with thin films of a non-magnetic dielectric insulator.

14. The biosensor platform system of claim 6 , wherein the dielectric thin films comprise a nanolaminate structure of differentially oriented magnetic moment films.

15. The biosensor platform system of claim 14 , wherein the nanolaminate structure comprises layers of a non-magnetic dielectric insulator intercalated between alternating sub stack layers of a first high-k dielectric ferromagnetic material and a second low-k dielectric ferromagnetic material.

Assignees

• Univ Leland Stanford Junior
• The Board Of Trustees Of The Leland Stanford Junio

Inventors

• Gupta Chaitanya

Classifications

• G01N27/3278 Primary

  involving nanosized elements, e.g. nanogaps or nanoparticles (nanopores G01N33/48721; magnetic beads G01N27/745) · CPC title

• B01L3/5027

  by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip · CPC title