Sensing platform for quantum transduction of chemical information

Patent metadata

Field	Value
Publication number	US-9285336-B2
Application number	US-201313963272-A
Country	US
Kind code	B2
Filing date	Aug 9, 2013
Priority date	Aug 9, 2012
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

A system for determining chemistry of a molecule in a high background interfering liquid environment by application of an electronic signal at a biased metal-electrolyte interface is disclosed. One or more of a resonant exchange of energy between one or more electrons exchanged by the metal and the electrolyte and vibrating bonds of a molecular analyte, for example, may be sensed by measuring small signal conductivity of an electrochemical interface.

First claim

At least the following is claimed:

1. A system for sensing chemical information, the system comprising:
a fluidic system, comprising:
a sample acquisition zone;
a filtration module coupled to the sample acquisition zone;
an immunoseparation module coupled to the filtration module;
a tapered micro-chromatogram coupled to the immunoseparation module; and
an adsorption pad coupled to the tapered micro-chromatogram; and

a quantum tunneling biosensor interface coupled to the adsorption pad, the quantum tunneling biosensor interface comprising:
a transducing electrode array comprising dielectric thin films deposited on an electrode array; and
sensor interface circuitry coupled to the transducing electrode array.

2. A system, comprising:
a quantum tunneling biosensor interface, comprising:
a transducing electrode array comprising dielectric thin films, the dielectric thin films being layered on a metal electrode array, the metal electrode array being mounted on a silicon die;
sensor interface circuitry coupled to the transducing electrode array; and
a voltage source to apply a voltage bias across the transducing electrode array to produce a weakly-coupled non-adiabatic electron flux.

3. The system of claim 2 , wherein the sensor interface circuitry is coupled to the transducing electrode array by through-silicon vias in the silicon die.

4. The system of claim 2 , further comprising a modular fluidic system, comprising:
a sample acquisition zone;
a coarse filtration module coupled to the sample acquisition zone;
an immunoseparation module coupled to the coarse filtration module;
a tapered micro-chromatograph coupled to the immunoseparation module; and
an adsorption pad coupled to the quantum tunneling biosensor interface.

5. The system of claim 4 , the quantum tunneling biosensor interface mounted on a shielded printed circuit board.

6. The system of claim 4 , the metal electrode array comprising a gold electrode.

7. The system of claim 4 , the dielectric thin films comprising a nanolaminate having a high dielectric constant.

8. The system of claim 7 , the nanolaminate comprising high dielectric constant layers and low dielectric constant layers, the high dielectric constant layers being intercalated between the low dielectric constant layers.

9. The system of claim 8 , the high dielectric constant layers comprising at least one material selected from the group consisting of:
HfO 2 ;
Ta 2 O 2 ;
ZrO 2 ; and
TiO 2 .

10. The system of claim 8 , the low dielectric constant layer comprising an organic alkane layer.

11. The system of claim 4 , the dielectric thin films comprising a nanolaminate to apply a directional magnetic field across the transducing electrode array.

12. The system of claim 4 , the dielectric thin films comprising layers of a non-magnetic dielectric insulator intercalated between substacks, the substacks comprising alternating layers of a first ferromagnetic material with a high dielectric constant and a second ferromagnetic material with a low dielectric constant.

13. The system of claim 12 , the non-magnetic dielectric insulator comprising Al 2 O 3 .

14. A system, comprising:
a quantum tunneling biosensor interface, comprising:
a transducing electrode sensor array comprising at least one dielectric thin film layered on an electrode array; and
sensor interface circuitry coupled to the transducing electrode sensor array; and

a fluidic module, comprising:
a sample acquisition zone;
an immunoseparation module in fluid communication with the sample acquisition zone; and
a tapered micro-chromatograph in fluid communication with the immunoseparation module and the quantum tunneling biosensor interface.

15. The system of claim 14 , wherein the fluidic module further comprises:
a coarse filtration module in fluid communication with the sample acquisition zone; and
an adsorption pad in fluid communication with the tapered micro-chromatograph and the quantum tunneling biosensor interface.

16. The system of claim 14 , wherein the transducing electrode sensor array comprises the at least one dielectric thin film layered on a metal electrode array.

17. The system of claim 14 , further comprising a voltage source to apply a voltage bias across the transducing electrode sensor array to produce a weakly-coupled non-adiabatic electron flux.

18. The system of claim 14 , the at least one dielectric thin film comprising a nanolaminate having a high dielectric constant.

19. The system of claim 14 , the at least one dielectric thin film comprising at least one high dielectric constant layer and at least one low dielectric constant layer.

20. The system of claim 19 , the at least one high dielectric constant layer comprising a material selected from the group consisting of:
Ta 2 O 2 ;
ZrO 2 ; and
TiO 2 .

Assignees

• Univ Leland Stanford Junior

Inventors

• Gupta Chaitanya

Classifications

• G01N33/561

  Immunoelectrophoresis · CPC title

• B82Y15/00 Primary

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title

• G01N33/6803

  General methods of protein analysis not limited to specific proteins or families of proteins · CPC title

• G01N27/4145 Primary

  specially adapted for biomolecules, e.g. gate electrode with immobilised receptors · CPC title

• G01N27/4148

  Integrated circuits therefor, e.g. fabricated by CMOS processing · CPC title