Closure system for an applicator attachment on a container for pharmaceutical preparations, and use, container with closure system, syringe for medical purposes, and method of assembly

Patent metadata

Field	Value
Publication number	US-10099012-B2
Application number	US-201314388328-A
Country	US
Kind code	B2
Filing date	Mar 19, 2013
Priority date	Apr 4, 2012
Publication date	Oct 16, 2018
Grant date	Oct 16, 2018

Abstract

Disclosed are a closure system for an applicator attachment on a container for pharmaceutical preparations and to a use of the closure system, a syringe for medical purposes, including a container for pharmaceutical preparations and a closure system, and a method of assembling a syringe. The aforementioned operate such that splash prevention and a venting function are integrated in the closure system.

First claim

The invention claimed is:

1. A closure system ( 1 ) for an applicator attachment ( 3 ) on a container ( 4 ) for pharmaceutical preparations, said applicator attachment extending along a theoretical longitudinal axis (AL), having a through-opening ( 2 ) and being designed for the connection of an applicator, said closure system comprising
a closure element ( 15 ) with at least one region having a sealing surface ( 16 ) for sealing the through-opening ( 2 ) of the applicator attachment ( 3 );
a sleeve-like connection element ( 57 ) for force-fitting and/or form-fitting connection to the container ( 4 ) at an end region thereof;
a closure securing unit ( 17 ) arranged coaxial with the connection element ( 57 ) and surrounding the latter in the circumferential direction, said closure securing unit comprising a securing ring ( 18 ) and a securing part ( 19 ) which is connected to the securing ring ( 18 ) via connecting means ( 20 ) so as to be separable with irreversible destruction of the latter, wherein the closure securing unit ( 17 ) is designed to surround at least the end region of the applicator attachment ( 3 ) and the closure element ( 15 ) in the circumferential direction around the longitudinal axis (AL) over a portion of the extension in the longitudinal direction and to fix the sleeve-like connection element ( 57 ) to the container ( 4 ) by a relative movement in the longitudinal direction relative to the connection element ( 57 ) from a first into a second assembled position; wherein;
the closure element ( 15 ) is detachably connected in a force-fitting and/or form-fitting manner at least indirectly to a connection part formed by the applicator attachment ( 3 ) or a by a functional element carrying the latter or by the securing ring ( 18 ), wherein the closure element ( 15 ) in a first functional position defined as the closed position closes the through-opening ( 2 ) on the applicator attachment ( 3 ) in a pressure-tight, media-tight and microbially tight manner, and the form-fitting and/or force-fitting connection ( 22 , 51 ) is arranged and designed in such a way as to be suitable for permitting, after the securing part ( 19 ) has been separated from the securing ring ( 18 ), a relative movement between the components involved in the connection ( 22 , 51 ), in particular the closure element ( 15 ) and the connection part, with a directional component in the direction of the longitudinal axis (AL) from the first functional position (closed position) into at least one further functional position (splash-preventing and/or venting position) while at least partially maintaining this connection ( 22 , 51 ), wherein in the at least one further functional position the pressure-tight, media-tight and microbially tight sealing of the through-opening ( 2 ) on the applicator attachment ( 3 ) by the closure element is canceled so as to form an intermediate space ( 32 ) that is formed between the closure element ( 15 ), the applicator attachment ( 3 ) and/or the connection part;
the closure system further comprises venting means ( 21 ) are provided, which are integrated at least partially in the at least indirect connection ( 22 , 51 ) between the closure element ( 15 ) and the connection part and are arranged and designed in such a way as to be suitable for connecting the through-opening ( 2 ) on the applicator attachment ( 3 ) to the surrounding environment at least in the second functional position of the closure element ( 15 ); and
in order to establish the connection ( 22 ) the holding part ( 30 ) carrying the closure element ( 15 ) comprises at least one external thread ( 25 ) which is arranged on a portion of its outer circumferential surface ( 31 ) with a directional component in the longitudinal direction and over a portion of the extension of the circumferential surface ( 24 ) in the longitudinal direction, which external thread engages with an internal thread ( 26 ) on a portion ( 27 ) extending in the direction of the longitudinal axis (AL) and forming an inner circumference, wherein the portion being designed to run in the circumferential direction around the longitudinal axis (AL) on a connection part and a venting channel as venting means is created by an interruption in the thread on the external thread ( 25 ) and/or internal thread ( 26 ), wherein said renting channel extends in the direction of the longitudinal axis (AL).

2. The closure system ( 1 ) according to claim 1 , wherein the at least indirect connection ( 22 , 51 ) between the closure element ( 15 ) and the connection part is formed indirectly by a connection between a holding part ( 30 ), which surrounds the closure element ( 15 ) as seen at least in the circumferential direction around the longitudinal axis (AL) and is connected thereto, and the connection part, and the connection between the closure element ( 15 ) and the holding part ( 30 ) is designed as one of the connections mentioned below or as a combination of these:
force-fitting connection
form-fitting connection
material bond
and
the form fit ( 31 ) which acts in the direction of the longitudinal axis (AL) and which is formed at least indirectly between the closure element ( 15 ) and the securing part ( 19 ) is formed between the holding part ( 30 ) and the securing part ( 19 ).

3. The closure system ( 1 ) according to claim 1 , wherein the at least indirect connection ( 22 , 51 ) between the closure element ( 15 ) and the connection part is formed by a direct connection of the closure element ( 15 ) and the connection part, and the form fit ( 31 ) which acts in the direction of the longitudinal axis (AL) and which is formed at least indirectly between the closure element ( 15 ) and the securing part ( 19 ) is formed between the closure element ( 15 ) and the securing part ( 19 ).

4. The closure system ( 1 ) according to claim 1 , wherein the at least indirect connection ( 22 , 51 ) which permits a relative movement between the closure element ( 15 ) and the connection element with a directional component in the direction of the longitudinal axis (AL) is designed at least over a portion with a form-fitting and/or force-fitting connection acting in the direction of the longitudinal axis (AL) counter to the detachment movement direction of the closure element ( 15 ).

5. The closure system ( 1 ) according to claim 1 , wherein the at least indirect connection ( 22 , 51 ) which permits a relative movement between the closure element ( 15 ) and the connection element with a directional component in the direction of the longitudinal axis (AL) is formed by a screw connection, comprising a portion with an internal thread on one of the components to be connected to one another—closure element ( 15 )/holding part ( 30 ) or connection part—and a portion with an external thread on the respective other of the components to be connected to one another—connection part or closure element ( 15 )/holding part ( 30 ).

6. The closure system ( 1 ) according to claim 5 , wherein at least one venting channel is provided which extends with at least a main directional component parallel to the longitudinal axis (AL) and which is incorporated in the thread or is formed by interrupting the thread turns so as to form thread-free regions on at least one of the components to be connected to one another—closure element ( 15 )/holding part ( 30 ) or connection part—wherein the thread-free regions are arranged and dimensioned in such a way that the sum of the thread-free angle regions is in the range from 5° to 90°, preferably 8° to 60°, particularly preferably 10° to 45°, relative to the full circumference 360°.

7. The closure system ( 1 ) according to claim 5 , wherein the further functional position (venting position) between the closure element ( 15 ) and the connection e

Assignees

• Boehringer Ingelheim Int

Inventors

• Haefele Friedrich
• Hemminger Markus
• Sachsse Tobias
• Boje Klaus

Classifications

• A61M2005/3123

  having air entrapping or venting means, e.g. purging channels in pistons · CPC title

• A61M2005/3106

  Plugs for syringes without needle · CPC title

• A61M5/3134 Primary

  characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula · CPC title

• B65D43/02

  Removable lids or covers (with means for piercing, cutting, or tearing a frangible inner closure B65D51/22) · CPC title

• B65B7/01

  Machines characterised by incorporation of means for making the closures before applying · CPC title