Purification method
US-9346771-B2 · May 24, 2016 · US
Synthesis of [18F]-fluoroalkyl tosylate
US10087141B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10087141-B2 |
| Application number | US-201414910493-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 21, 2014 |
| Priority date | Aug 22, 2013 |
| Publication date | Oct 2, 2018 |
| Grant date | Oct 2, 2018 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
[18F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [18F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [18F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of purifying crude [ 18 F]2-fluoroethyl tosylate using a positron-emission tomography (PET) tracer production platform that comprises a cassette-based chemical synthesizer and the cassette comprises fluid pathways, a reaction vessel, ports for receiving reagent vials as well as a solid phase extraction (SPE) cartridge, the method comprising, reacting ethylene ditosylate with a source of 18 F- to form the crude [ 18 F]2-fluoroethyl tosylate using the chemical synthesizer; and purifying said crude [ 18 F]2-fluoroethyl tosylate with SPE on the SPE cartridge. 2. The method of claim 1 , wherein the SPE cartridge is a tC18 column using acetonitrile eluents. 3. The method of claim 1 , wherein the SPE cartridge is a tC2 column. 4. The method of claim 1 , wherein the SPE cartridge is a C30 column. 5. A method of purifying crude [ 18 F]2-fluoroalkyl tosylate using a positron-emission tomography (PET) tracer production platform that comprises a cassette-based chemical synthesizer and the cassette comprises fluid pathways, a reaction vessel, ports for receiving reagent vials as well as a solid phase extraction (SPE) cartridge, the method comprising, purifying said crude [ 18 F]2-fluoroalkyl tosylate with SPE on the SPE cartridge. 6. The method of claim 5 , wherein the SPE cartridge is a tC2 column. 7. The method of claim 5 , wherein the SPE cartridge is a tC18 column. 8. The method of claim 5 , wherein the SPE cartridge is a C30 column. 9. The method of claim 5 , wherein the [ 18 F]2-fluoroalkyl tosylate is [ 18 F]2-fluoromethyl tosylate. 10. The method of claim 5 , wherein the [ 18 F]2-fluoroalkyl tosylate is [ 18 F]2-fluoropropyl tosylate. 11. A method of purifying crude [ 18 F]2-fluoroethyl tosylate using a positron-emission tomography (PET) tracer production platform that comprises a cassette-based chemical synthesizer and the cassette comprises fluid pathways, a reaction vessel, ports for receiving reagent vials as well as a solid phase extraction (SPE) cartridge, the method comprising, purifying said crude [ 18 F]2-fluoroethyl tosylate with SPE on the SPE cartridge. 12. The method of claim 11 , wherein the SPE cartridge is a tC2 column. 13. The method of claim 11 , wherein the SPE cartridge is a tC18 column. 14. The method of claim 11 , wherein the SPE cartridge is a C30 column.
Assignees
Inventors
Classifications
Isotopically modified compounds, e.g. labelled · CPC title
- C07B59/001Primary
Acyclic or carbocyclic compounds · CPC title
by reactions not involving the formation of esterified sulfo groups · CPC title
Stationary reactors without moving elements inside (B01J19/08, B01J19/26 take precedence; with stationary particles B01J8/02) · CPC title
- C07C303/22Primary
from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; {from sulfonic halides by reactions not involving the formation of halosulfonyl groups} · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10087141B2 cover?
- [18F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [18F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [18F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.
- Who is the assignee on this patent?
- Ge Healthcare Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07B59/001. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 02 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).