Endoluminal prosthetic assemblies, and associated systems and methods for percutaneous repair of a vascular tissue defect

Patent metadata

Field	Value
Publication number	US-10070950-B2
Application number	US-201615019877-A
Country	US
Kind code	B2
Filing date	Feb 9, 2016
Priority date	Feb 9, 2016
Publication date	Sep 11, 2018
Grant date	Sep 11, 2018

Abstract

A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

First claim

What is claimed is:

1. A prosthetic assembly for repairing a target tissue defect within a target vessel region in a patient, the prosthetic assembly comprising:
an exclusion structure sized to substantially cover the target tissue defect in the target vessel region when the exclusion structure is in a deployed configuration; and
a branch assembly for directing fluid flow to a branch vessel from the target vessel region, the branch assembly comprising,
an outer branch prosthesis having a first portion and a second portion, wherein the first portion is configured to be deployed between the exclusion structure and a wall of the target vessel region, and the second portion is configured to be deployed in the branch vessel branching from the target vessel region, the first and second portions of the outer branch prosthesis including a stent and graft material, and
a support structure at least partially disposed within the outer branch prosthesis at the first portion when the branch assembly is in a deployed configuration,
wherein an inflow region of the first portion of the outer branch prosthesis is expandable to a cross-sectional dimension larger than a cross-sectional dimension of the support structure, and wherein the first portion is deformable to a non-circular cross-sectional shape when deployed.

2. The prosthetic assembly of claim 1 , wherein the inflow region is configured to deform to the non-circular cross-sectional shape to conform to the wall of the target vessel region and an outer surface of the exclusion structure.

3. The prosthetic assembly of claim 1 , wherein the cross-sectional shape of the support structure remains sufficiently stable when the inflow region of the outer branch prosthesis is deformed to the non-circular cross-sectional shape.

4. The prosthetic assembly of claim 3 , wherein the support structure is substantially circular in cross-section to maintain patency of the first portion of the outer branch prosthesis.

5. The prosthetic assembly of claim 1 , wherein at least a portion of the stent at the first portion of the outer branch prosthesis comprises two or more posts oriented lengthwise along the first portion, and wherein the posts provide a deformation orientation plane such that when deformed, the cross-sectional shape is substantially elliptical.

6. The prosthetic assembly of claim 1 , wherein the inflow region is configured to be deformable to an oval cross-sectional shape by the exclusion structure when the prosthetic assembly is deployed at the target vessel region.

7. The prosthetic assembly of claim 1 , wherein the inflow region has a first cross-sectional dimension and the second portion has a second cross-sectional dimension less than the first cross-sectional dimension.

8. The prosthetic assembly of claim 1 , wherein the support structure has a central longitudinal axis and a first radial strength oriented in an outward, radial direction from the central longitudinal axis, and wherein the first portion of the outer branch prosthesis has a second radial strength oriented in an outward, radial direction from the central longitudinal axis, and wherein the second radial strength is less than the first radial strength.

9. The prosthetic assembly of claim 1 , wherein the first portion of the outer branch prosthesis has a central longitudinal axis, and wherein the support structure is configured to be deployed coaxially with the first portion of the branch stent along the central longitudinal axis.

10. The prosthetic assembly of claim 1 , wherein the support structure is a balloon-expandable stent.

11. The prosthetic assembly of claim 1 , wherein the support structure is a self-expanding stent.

12. The prosthetic assembly of claim 1 , wherein the exclusion structure is an endoprosthetic stent-graft and a proximal portion of the branch assembly is configured to be deployed in parallel with a proximal portion of the endoprosthetic stent-graft.

13. The prosthetic assembly of claim 12 , wherein the target tissue defect is an abdominal aortic aneurism, and wherein the endoprosthetic stent-graft is configured to be implanted in the aorta in a manner to bypass the aneurism.

14. The prosthetic assembly of claim 1 , further comprising a second branch assembly for directing fluid flow to a second branch vessel from the target vessel region.

15. The prosthetic assembly of claim 1 , wherein the support structure includes an upstream end and a downstream end, and wherein the upstream end extends a distance in an upstream direction beyond a proximal end of the first portion of the outer branch prosthesis.

16. The prosthetic assembly of claim 1 , wherein the inflow region of the outer branch prosthesis includes a rim at a proximal end of the inflow region, the rim having an undeformed configuration, the undeformed configuration having a generally circular shape.

17. The prosthetic assembly of claim 1 , wherein the support structure has a longitudinal axis, and wherein the inflow region of the outer branch assembly in a radially expanded, unconstrained configuration flares outward from the longitudinal axis by a taper angle.

18. The prosthetic assembly of claim 17 , wherein the taper angle continuously changes between a transition point of the inflow region and a rim at a proximal end of the inflow region.

19. The prosthetic assembly of claim 1 , wherein:
the first portion of the outer branch prosthesis includes a plurality of first struts interconnected around a circumference of the first portion;
the support structure includes a plurality of second struts interconnected around a circumference of the support structure; and
the second struts are more rigid than the first struts.

20. The prosthetic assembly of claim 1 , wherein the first portion of the outer branch prosthesis has a frustoconical shape in a radially expanded, unconstrained configuration.

21. The prosthetic assembly of claim 1 , wherein the exclusion structure is configured to provide a compressive force against the branch assembly, and wherein the compressive force is sufficient to deform the outer branch prosthesis without substantially deforming the support structure deployed within the outer branch prosthesis.

22. The prosthetic assembly of claim 1 , wherein a distal end of the second portion of the outer branch prosthesis is open to permit fluid flow therethrough.

Assignees

• Medtronic Vascular Inc

Inventors

• Piccagli Francesco
• Argentine Jeffery
• Coghlan Kieran
• Guala Carlo
• Morero Massimo
• Galligan Darren

Classifications

• A61F2/852

  Two or more distinct overlapping stents · CPC title

• A61F2250/0039

  differing in diameter · CPC title

• A61F2250/0003

  having an inflatable pocket filled with fluid, e.g. liquid or gas · CPC title

• A61F2/95

  Instruments specially adapted for placement or removal of stents or stent-grafts · CPC title

• A61F2002/061

  provided with means for allowing access to secondary lumens · CPC title