Aminotriazine derivative and pharmaceutical composition comprising the same
US-9732060-B2 · Aug 15, 2017 · US
US10065941B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10065941-B2 |
| Application number | US-201715637967-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 29, 2017 |
| Priority date | Jun 14, 2013 |
| Publication date | Sep 4, 2018 |
| Grant date | Sep 4, 2018 |
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The present invention provides novel compounds having a P2X 3 and/or P2X 2/3 receptor antagonistic activity. A compound of Formula (I): wherein R a and R b , and R d and R e are taken together to form oxo or the like; R 4a and R 4b are hydrogen or the like; n is 1 or the like; R 2 is aryl or the like; s and s′ is 0 or the like; R 9 and R 9 ′ are halogen or the like; R 20a and R 20b are hydrogen, alkyl or the like; u is 1 to 4; R 13 is hydrogen or the like, or its pharmaceutically acceptable salt.
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The invention claimed is: 1. A method for treating pain, comprising administering to a person in need thereof a pharmaceutically effective amount of a compound: or its pharmaceutically acceptable salt. 2. The method according to claim 1 , wherein the compound is the following formula: or its pharmaceutically acceptable salt. 3. The method according to claim 1 , wherein the compound is the following formula: or its pharmaceutically acceptable salt. 4. The method according to claim 1 , wherein the compound is the following formula: or its pharmaceutically acceptable salt.
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