Aminotriazine derivative and pharmaceutical composition comprising the same

Patent metadata

Field	Value
Publication number	US-9732060-B2
Application number	US-201414897836-A
Country	US
Kind code	B2
Filing date	Jun 13, 2014
Priority date	Jun 14, 2013
Publication date	Aug 15, 2017
Grant date	Aug 15, 2017

Abstract

The present invention provides novel compounds having a P2X 3 and/or P2X 2/3 receptor antagonistic activity.
A compound of Formula (I):

wherein R a and R b , and R d and R e are taken together to form oxo or the like; R 4a and R 4b are hydrogen or the like; n is 1 or the like; R 2 is aryl or the like; s and s′ is 0 or the like; R 9 and R 9 ′ are halogen or the like; R 20a and R 20b are hydrogen, alkyl or the like; u is 1 to 4; R 13 is hydrogen or the like, or its pharmaceutically acceptable salt.

First claim

The invention claimed is:

1. A compound of formula:

or its pharmaceutically acceptable salt.

2. A pharmaceutical composition comprising the compound according to claim 1 , or its pharmaceutically acceptable salt, and further comprising a pharmaceutical additive.

3. The pharmaceutical composition according to claim 2 , wherein the composition has a P2X 3 and/or P2X 2/3 receptor antagonistic activity.

4. The compound according to claim 1 , chosen from a compound of the following formula:

or its pharmaceutically acceptable salt.

5. The compound according to claim 1 , chosen from a compound of the following formula:

or its pharmaceutically acceptable salt.

6. The compound according to claim 1 , chosen from a compound of the following formula:

or its pharmaceutically acceptable salt.

7. A pharmaceutical composition comprising the compound according to any one of claims 4 , 5 and 6 , or its pharmaceutically acceptable salt, and further comprising a pharmaceutical additive.

8. The pharmaceutical composition according to claim 7 , wherein the composition has a P2X 3 and/or P2X 2/3 receptor antagonistic activity.

Assignees

• Shionogi & Co

Inventors

• Kai Hiroyuki

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• C07D409/14

  containing three or more hetero rings · CPC title

• C07D405/14

  containing three or more hetero rings · CPC title

• A61K31/53

  having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine (melarsoprol A61K31/555 {; with four nitrogen atoms A61K31/495}) · CPC title