Precision blood fluid removal therapy based on patient monitoring

Patent metadata

Field	Value
Publication number	US-10064985-B2
Application number	US-201615384912-A
Country	US
Kind code	B2
Filing date	Dec 20, 2016
Priority date	Apr 29, 2011
Publication date	Sep 4, 2018
Grant date	Sep 4, 2018

Abstract

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

First claim

What is claimed is:

1. A non-transitory computer-readable storage medium with an executable program stored thereon comprising instructions that, when executed by one or more programmable computer systems incorporated into a blood fluid removal device, cause the blood fluid removal device to execute the following steps:
acquire first patient data of a first blood fluid removal session regarding one or more of (i) one or more patient physiological parameters; and (ii) time since a last blood fluid removal session before an upcoming blood fluid removal session;
acquire data regarding one or more target outcomes of each blood fluid removal session;
compare the data regarding the at least one of the target outcomes of each blood fluid removal session to corresponding data regarding at least one prior patient outcome stored in a lookup table; wherein the lookup table comprises data regarding system parameters used in the one or more prior blood fluid removal sessions of the patient and comprises prior patient data prior to a first session regarding one or more of (i) one or more patient physiological parameters and (ii) time since the prior blood fluid removal session before a corresponding upcoming blood fluid removal session;
compare the first patient data to the corresponding prior patient data stored in the lookup table;
initiate the upcoming blood fluid removal session employing the system parameters used in the prior blood fluid removal session if the at least one of the one or more target outcomes is within a predetermined range of the corresponding data regarding the at least one prior patient outcome stored in the lookup table and the patient data is within a predetermined range of the corresponding prior patient data.

2. A method carried out by a blood fluid removal system,
wherein the blood fluid removal system comprises:
(a) a blood fluid removal medium to remove blood from the patient, wherein the blood enters the medium, a fluid contained in the blood is removed from the blood, and the blood exits the medium;
(b) one or more control elements to control (i) a rate at which the medium removes fluid from the blood or (ii) concentration of electrolytes or pH in the blood that exits the medium;
(c) one or more sensors to monitor one or more physiological parameters of the patient wherein the physiological parameters are one or more selected from the group consisting of blood pressure, heart rate, pH, and electrolyte concentration, the one or more sensors sensing signals from one or more of the blood and a tissue of the patient; and
(d) control electronics comprising memory and a processor, wherein the control electronics are in operable communication with the one or more sensors and are operably coupled to the one or more control elements,
wherein the control electronics are programmed to carry out the method, comprising:
acquiring first patient data of a first blood fluid removal session regarding one or more of: (i) the one or more patient physiological parameters; and (ii) time since a last blood fluid removal session before an upcoming blood fluid removal session;
acquiring data regarding one or more target outcomes of each blood fluid removal session;
comparing the data regarding at least one of the one or more target outcomes of each blood fluid removal session to corresponding data regarding at least one prior patient outcome stored in a lookup table, wherein the lookup table comprises data regarding system parameters used in the one or more prior blood fluid removal sessions of the patient and comprises prior patient data prior to the first session regarding one or more of (i) one or more patient physiological parameters; and (ii) time since the prior blood fluid removal session before a corresponding upcoming blood fluid removal session;
comparing the first patient data to the corresponding prior patient data stored in the lookup table;
initiating the upcoming blood fluid removal session employing the system parameters used in the prior blood fluid removal session if the at least one of the one or more target outcomes is within a predetermined range of the corresponding data regarding the at least one prior patient outcome stored in the lookup table and the patient data is within a predetermined range of the corresponding prior patient data stored in the lookup table.

3. The method of claim 2 , wherein the at least one of the one or more patient parameters comprise the concentration of an electrolyte.

4. The method of claim 3 , wherein the electrolyte is potassium.

5. The method of claim 2 , wherein the system parameters comprise one or more of fluid removal rate and concentration of one or more electrolyte.

6. A blood fluid removal system, comprising:
a blood fluid removal medium configured to remove blood from a patient, wherein blood enters the medium, fluid is removed from the blood, and blood exits the medium;
one or more control elements configured to control (i) the rate at which the medium removed fluid from the blood or (ii) the concentration of electrolytes or pH in the blood that exits the medium;
one or more sensors configured monitor one or more physiological parameter of the patient;
an input configured to allow entry of data regarding patient or system parameters; and
control electronics comprising memory and a processor, wherein the control electronics are in operable communication with the one or more sensors and are operably coupled to the one or more control elements and the input,
wherein the control electronics are programmed to carry out a method according to claim 2 .

7. The system of claim 6 , wherein the blood fluid removal medium and the control electronics are housed within a blood fluid removal device.

8. The system of claim 6 , further comprising a computer readable, wherein the computer readable medium comprises instructions that cause the control electronics to carry out the method according claim 2 .

9. A blood fluid removal system comprising:
a blood fluid removal medium configured to remove blood from a patient, wherein blood enters the medium, fluid is removed from the blood, and blood exits the medium;
one or more control elements configured to control (i) the rate at which the medium removed fluid from the blood or (ii) the concentration of electrolytes or pH in the blood that exits the medium;
one or more sensors configured monitor one or more physiological parameter of the patient;
an input configured to allow entry of data regarding patient or system parameters; and
control electronics comprising memory and a processor, wherein the control electronics are in operable communication with the one or more sensors and are operably coupled to the one or more control elements and the input,
wherein the control electronics are programmed to:
acquire data regarding one or more of: one or more patient physiological parameters; and time since last blood fluid removal session;
acquire data regarding one or more target outcomes of a blood fluid removal session;
compare the data regarding at least one of the one or more target outcomes of the blood fluid removal session to corresponding data regarding at least one prior patient outcome stored in a lookup table, wherein the lookup table comprises data regarding system parameters used in one or more prior blood fluid removal sessions of the patient and comprises patient data prior to the previous session regarding one or more of (i) one or more patient physiological parameters; and (ii) time since last blood fluid removal session;
compare the data regarding the one or more of (i) one or more patient physiological parameters; and (ii) time since last blood fluid removal session to corresponding patient data prior to the pr

Assignees

• Medtronic Inc

Inventors

• Gerber Martin
• Lyu Suping
• Pudil Bryant

Classifications

• A61M1/1607

  before use, i.e. upstream of dialyser · CPC title

• A61M1/00

  Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems (catheters A61M25/00; tube connectors, tube couplings, valves or branch units specially adapted for medical use A61M39/00; devices for taking samples of blood A61B5/15; filters implantable into blood vessels A61F2/01) · CPC title

• A61M1/1601

  Control or regulation · CPC title

• B01D2321/40

  Automatic control of cleaning processes · CPC title

• A61B5/145

  Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value {; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue} (non-radiation detecting or locating of foreign bodies in blood A61B5/06) · CPC title