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US-9201069-B2 · Dec 1, 2015 · US
Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate
US10060918B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10060918-B2 |
| Application number | US-201615396128-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 30, 2016 |
| Priority date | Dec 29, 2006 |
| Publication date | Aug 28, 2018 |
| Grant date | Aug 28, 2018 |
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Abstract
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Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.
First claim
Opening claim text (preview).
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. A crosslinked polymer having a plurality of target binding partners covalently coupled thereto, wherein the crosslinked polymer comprises a plurality of carboxylic acid groups and a plurality of positive charged groups, wherein the crosslinked polymer is substantially electronically neutral and is a crosslinked poly(carboxybetaine) hydrogel, wherein the target binding partner is selected from the group consisting of enzymes, antibodies, antigens, receptors, and ligands, and wherein the target binding partner has affinity toward a target molecule. 2. The crosslinked polymer of claim 1 , wherein the crosslinked poly(carboxbetaine) is prepared from one or more monomers selected from the group consisting of carboxybetaine acrylates, carboxybetaine acrylamides, carboxybetaine vinyl compounds, carboxybetaine epoxides, and mixtures thereof.
Assignees
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Classifications
with ligand attached to the carrier via a chemical coupling agent (coatings G01N33/54393) · CPC title
Esters containing nitrogen · CPC title
- G01N33/545Primary
Synthetic resin · CPC title
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Frequently asked questions
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- What does patent US10060918B2 cover?
- Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (…
- Who is the assignee on this patent?
- Univ Washington
- What technology area does this patent fall under?
- Primary CPC classification G01N33/545. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).