Substituted 2,3,4,5,7,9,13,13a-octahydro-1,5-methanopyrido[1′,2′:4,5]pyrazino[1,2-a][1,3]diazepines and methods for treating viral infections

Patent metadata

Field	Value
Publication number	US-10035809-B2
Application number	US-201715599151-A
Country	US
Kind code	B2
Filing date	May 18, 2017
Priority date	Dec 21, 2012
Publication date	Jul 31, 2018
Grant date	Jul 31, 2018

Abstract

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , X, W, Y 1 , Y 2 , Z 1 , and Z 4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

First claim

What is claimed is:

1. A compound having Formula (I):

or a stereoisomer or pharmaceutically acceptable salt thereof,
wherein:
X is —NZ 3 —;
W is —CHZ 2 —;
Z 2 is hydrogen;
Z 1 and Z 3 , taken together, form -L-, wherein L is —C(R a ) 2 —;
Z 4 is —CH 2 CH 2 —;
Y 1 and Y 2 are each independently hydrogen, C 1-3 alkyl or C 1-3 haloalkyl;
R 1 is phenyl substituted with one, two or three halogens; and
each R a is, independently, hydrogen, halogen, hydroxy or C 1-4 alkyl.

2. The compound of claim 1 , wherein the compound is selected from the group consisting of:

3. A pharmaceutical composition comprising a compound of claim 1 , or a stereoisomer or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

Assignees

• Gilead Sciences Inc

Inventors

• Bacon Elizabeth M
• Cai Zhenhong R
• Chen Xiaowu
• Cottell Jeromy J
• Desai Manoj C
• Ji Mingzhe
• Jin Haolun
• Lazerwith Scott E
• Mish Michael R
• Morganelli Philip Anthony
• Pyun Hyung-Jung
• Taylor James G
• Trejo Martin Teresa Alejandra

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/18

  for HIV · CPC title

• A61P31/12

  Antivirals · CPC title

• C07D471/18 Primary

  Bridged systems · CPC title

• A61K31/537

  spiro-condensed or forming part of bridged ring systems · CPC title