Thin film polymer structure having different modification on opposite sides thereof

Patent metadata

Field	Value
Publication number	US-10035337-B2
Application number	US-31206907-A
Country	US
Kind code	B2
Filing date	Oct 29, 2007
Priority date	Oct 27, 2006
Publication date	Jul 31, 2018
Grant date	Jul 31, 2018

Abstract

A method for preparing a thin film polymer structure having a functional substance on an A surface and a B surface of the film, the polymer structure being obtained by: (a) adsorbing polyfunctional molecules to a region of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then forming a soluble support film on the A surface; (d) exfoliating the thin film and the soluble support film from the substrate body; and (e) bonding to the B surface of the thin film a functional substance identical to or different from the functional substance bonded to the A surface and then dissolving the soluble support film with a solvent.

First claim

The invention claimed is:

1. A method for preparing a thin film polymer structure,
wherein the thin film polymer structure prepared by the method has two faces, one face being each of the opposite sides of the thin film polymer structure, and has a different functional substance bound to each of the two faces, said thin film polymer structure being obtained by the steps of:
(a) adsorbing polyfunctional molecules to an arbitrarily shaped region of a substrate body in an interface between the substrate body and a liquid phase, wherein the polyfunctional molecules are at least one polyfunctional macromer selected from the group consisting of polylactic acid, polylactic acid/glycolic acid copolymer, and polycaprolactone, provided that said polyfunctional macromer is not a polymer bead;
(b) crosslinking the adsorbing polyfunctional molecules by thermally crosslinking the polyfunctional molecules at 60-120° C. to form a polymer thin film having two faces, an exposed face referred to as an A surface and a reverse face on the opposite side of the thin film facing the substrate body, the reverse face referred to as a B surface;
(c) bonding a functional substance to the A surface of the formed polymer thin film and then forming a soluble support film directly atop the A surface inclusive of the bonded functional substance of the polymer thin film by application of an aqueous solution comprising a soluble support film polymer to the A surface inclusive of the bonded functional substance of the polymer thin film, wherein the soluble support film is formed of polyethylene glycol, polyacrylamide, polyvinyl alcohol or polysaccharide, said polysaccharide excluding cellulose acetate, and wherein the A surface inclusive of the bonded functional substance of the polymer thin film bonds to the soluble support film solely by secondary bonding forces between the A surface inclusive of the bonded functional substance of the polymer thin film and the soluble support film;
(d) exfoliating the polymer thin film and the soluble support film from the substrate body in step (a);
(e) bonding to the B surface of the polymer thin film a functional substance different from the functional substance in step (c); and
(f) dissolving the soluble support film with a solvent to release a thin film polymer structure having a different functional substance on the A surface and the B surface of the thin film polymer structure.

2. A method according to claim 1 wherein the functional substance on the A surface or the B surface is at least one of the following selected from the group consisting of a polymer compound, a polyelectrolyte, a protein, a peptide, a polysaccharide and a biotin derivative.

3. A method according to claim 2 wherein the polymer compound comprises poly(ethyleneglycol).

4. A method according to claim 1 wherein the substrate body is entirely or partially formed of at least one of the following selected from the group consisting of a metal or an oxide cover layer thereof, silicon, silicon rubber, silica, glass, mica, graphite, an organic polymer, and apatite.

5. A method according to claim 1 , wherein the solvent is selected from acetone, ethyl acetate, an alcohol, water, or an aqueous solution and will not dissolve the thin film polymer structure.

6. A method for preparing a dispersion comprising:
preparing a thin film polymer structure by the method according to claim 1 ; and
dispersing the structure in a liquid.

7. A method for preparing a thin film polymer structure comprising:
preparing a thin film polymer structure by the method according to claim 1 ; and adhering the structure at an interface.

8. A method according to claim 7 wherein the interface is at least one of the following surfaces selected from the group consisting of: a cell, a tissue, an internal organ, a vascular wall, a mucous membrane; a cornea, skin, hair and a nail.

9. The method according to claim 1 , wherein the secondary bonding force is selected from the group consisting of electrostatic interaction, hydrogen bonding and Van der Waals' force.

10. A method according to claim 1 wherein the soluble support film is formed of polyethylene glycol, polyvinyl alcohol or polysaccharide, said polysaccharide excluding cellulose acetate.

11. A method according to claim 1 wherein the step of exfoliating the polymer thin film and the soluble support film from the substrate body in step (a) is achieved by transferring the polymer thin film from the substrate body to the soluble support film by a hydrogen bonding.

12. A method according to claim 1 wherein the solvent is water.

13. The method according to claim 1 , wherein the solvent consists essentially of acetone, ethyl acetate, an alcohol, water, or mixtures thereof.

Assignees

• Takeoka Shinji
• Okamura Yosuke
• Fujie Toshinori
• Utsunomiya Saori
• Goto Takahiro
• Nanotheta Co Ltd
• Toray Industries

Inventors

• Takeoka Shinji
• Okamura Yosuke
• Fujie Toshinori
• Utsunomiya Saori
• Goto Takahiro

Classifications

• B32B38/10

  Removing layers, or parts of layers, mechanically or chemically · CPC title

• B32B37/02 Primary

  characterised by a sequence of laminating steps, e.g. by adding new layers at consecutive laminating stations · CPC title

• Y10T156/10

  Methods of surface bonding and/or assembly therefor · CPC title

• C08J5/18 Primary

  Manufacture of films or sheets · CPC title

• Y10T428/31504

  Composite [nonstructural laminate] · CPC title