Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

Patent metadata

Field	Value
Publication number	US-10034879-B2
Application number	US-201715852406-A
Country	US
Kind code	B2
Filing date	Dec 22, 2017
Priority date	Dec 28, 2011
Publication date	Jul 31, 2018
Grant date	Jul 31, 2018

Abstract

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

First claim

What is claimed is:

1. A compound having the structure:

2. A solid dosage form comprising a compound having the structure:

and a pharmaceutically acceptable excipient.

Assignees

• Global Blood Therapeutics Inc

Inventors

• Metcalf Brian
• Chuang Chihyuan

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P7/06

  Antianaemics · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title