Tomatidine, analogs thereof, compositions comprising same, and uses for same

Patent metadata

Field	Value
Publication number	US-10022386-B2
Application number	US-201514978886-A
Country	US
Kind code	B2
Filing date	Dec 22, 2015
Priority date	Aug 3, 2012
Publication date	Jul 17, 2018
Grant date	Jul 17, 2018

Abstract

In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

First claim

What is claimed is:

1. A method of
increasing muscle formation,
increasing muscle protein synthesis,
reducing skeletal muscle atrophy,
increasing the ratio of skeletal muscle to fat, or
decreasing adiposity

in an animal comprising administering to an animal in need thereof a composition comprising not less than 0.05% by weight of a compound selected from the group consisting of α-tomatine and a compound having a structure represented by a formula:

wherein
R 51 is selected from H, C 1 -C 6 alkyl, and COR 53 ;
R 53 is C 1 -C 6 alkyl;
Z 51 is NR 54 ; and
R 54 is selected from H and C 1 -C 6 alkyl,
or pharmaceutically acceptable salt thereof.

2. The method according to claim 1 , wherein the compound is a compound having a structure represented by the formula E1

or pharmaceutically acceptable salt thereof.

3. The method according to claim 2 wherein R 51 is selected from H and C 1 -C 6 alkyl.

4. The method according to claim 3 wherein R 51 is H and R 54 is H.

5. The method according to claim 2 wherein the compound is a compound having the structure represented by formula:

or pharmaceutically acceptable salt thereof.

6. The method according to claim 1 wherein said composition comprises not less than 0.14% by weight of said compound or pharmaceutically acceptable salt thereof.

7. The method according to claim 1 wherein said composition comprises not less than 0.28% by weight of said compound or pharmaceutically acceptable salt thereof.

8. The method according to claim 2 wherein the compound or pharmaceutically acceptable salt thereof is present in an amount greater than 5 mg.

9. The method according to claim 1 wherein the composition is a solution, dispersion, suspension or emulsion.

10. The method according to claim 1 , wherein said composition is a nutraceutical, animal chow, medicinal food, energy bar, energy drink, sports drink, protein bar, tea, coffee, milk, milk product, cereal, oatmeal, infant formula, or supplement.

11. The method according to claim 10 , wherein the compound is α-tomatine.

12. The method according to claim 10 , comprising administering the composition orally, and wherein the composition comprises a preservative.

13. The method according to claim 12 , wherein the composition is animal chow.

14. The method according to claim 13 , wherein the animal chow additionally comprises at least one further additive selected from the group consisting of flavoring agents, coloring agents, and binders.

15. The method according to claim 1 , wherein the compound is α-tomatine or a pharmaceutically acceptable salt thereof.

16. The method according to claim 1 , wherein the composition is a capsule or tablet.

17. The method according to claim 1 , wherein the animal is a non-human primate, horse, pig, rabbit, dog, sheep, goat, cow, cat, guinea pig, fish, or bird, and wherein the compound is selected from:
α-tomatine; and
a compound having a structure represented by a formula:

or pharmaceutically acceptable salt thereof.

18. A method of
increasing muscle formation,
increasing muscle protein synthesis,
reducing skeletal muscle atrophy,
increasing the ratio of skeletal muscle to fat, or
decreasing adiposity

in an animal in need of increased muscle formation, increased muscle protein synthesis, reduced skeletal muscle atrophy, increased ratio of skeletal muscle to fat, or decreased adiposity, the method comprising administering to the animal a composition selected from a nutraceutical, animal chow, medicinal food, energy bar, energy drink, sports drink, protein bar, tea, coffee, milk, milk product, cereal, oatmeal, infant formula, and supplement, wherein said composition provides a compound selected from the group consisting of α-tomatine and a compound having a structure represented by a formula:

wherein
R 51 is selected from H, C 1 -C 6 alkyl, and COR 53 ;
R 53 is C 1 -C 6 alkyl;
Z 51 is NR 54 ; and
R 54 is selected from H and C 1 -C 6 alkyl,

or pharmaceutically acceptable salt thereof.

19. The method according to claim 18 , comprising administering the composition so as to provide to the animal 0.1 to 250 mg/kg per day of the compound or pharmaceutically acceptable salt thereof.

20. The method according to claim 18 , comprising administering the composition so as to provide to the animal 0.5 to 100 mg/kg per day of the compound or pharmaceutically acceptable salt thereof.

21. The method according to claim 18 , comprising administering the composition so as to provide to the animal 5.0 to 100 mg/kg per day of the compound or pharmaceutically acceptable salt thereof.

22. The method according claim 21 , comprising administering the composition so as to provide to the animal greater than 50 mg per day of the compound or pharmaceutically acceptable salt thereof.

23. The method according to claim 22 , comprising administering the composition orally, wherein the composition comprises at least one further additive selected from the group consisting of preservatives, flavoring agents, coloring agents, and binders, and wherein the compound is a compound having a structure represented by the formula E1 or a pharmaceutically acceptable salt thereof.

24. The method according to claim 18 , wherein the animal is a non-human primate, horse, pig, rabbit, dog, sheep, goat, cow, cat, guinea pig, fish, or bird, wherein the composition is a nutraceutical, animal chow, medicinal food, or supplement, and wherein said composition provides a compound selected from the group consisting of α-tomatine and a compound and wherein the compound is selected from:
α-tomatine; and
a compound having a structure represented by a formula:

or pharmaceutically acceptable salt thereof.

25. The method according to claim 18 , wherein the composition provides greater than 5 mg of the compound or pharmaceutically acceptable salt thereof.

Assignees

• Univ Iowa Res Found
• Us Veterans Affairs

Inventors

• Adams Christopher M
• Dyle Michael C
• Welsh Michael

Classifications

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A61K31/58 Primary

  containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin (digitoxin {A61K31/7048}) · CPC title

• A23K20/121

  containing oxygen or sulfur as hetero atom · CPC title

• C12Q2600/158

  Expression markers · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title