Tomatidine, analogs thereof, compositions comprising same, and uses for same

Patent metadata

Field	Value
Publication number	US-9254295-B2
Application number	US-201514612636-A
Country	US
Kind code	B2
Filing date	Feb 3, 2015
Priority date	Aug 3, 2012
Publication date	Feb 9, 2016
Grant date	Feb 9, 2016

Abstract

In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

First claim

What is claimed is:

1. A method for promoting muscle health, normal muscle function, and/or healthy aging of muscle in skeletal muscle in an animal comprising administering to the animal a solution, dispersion, suspension or emulsion comprising not less than 0.14% by weight of a compound having a structure represented by a formula:

wherein
R 51 is selected from H, C 1 -C 6 alkyl, and COR 53 ;
R 53 is C 1 -C 6 alkyl;
Z 51 is NR 54 ; and
R 54 is selected from H and C 1 -C 6 alkyl,
or pharmaceutically acceptable salt thereof,
thereby promoting muscle health, normal muscle function, and/or healthy aging of muscle as measured by one or more of (1) increased muscle formation, (2) decreased muscle atrophy, (3) increased muscle hypertrophy, (4) increased exercise capacity, (5) increased muscle protein synthesis, (6) increased muscle mitochondria, (7) increased muscle force generation, (8) increased muscle strength, or (9) increased anabolic signaling in the skeletal muscle of the animal.

2. The method according to claim 1 wherein the compound has a structure represented by the formula E1

3. The method according to claim 1 wherein R 51 is selected from H and C 1 -C 6 alkyl.

4. The method according to claim 1 wherein R 51 is H.

5. The method according to claim 1 wherein R 54 is H.

6. The method according to claim 1 wherein the compound has the structure represented by formula:

7. The method according to claim 1 wherein said solution, dispersion, suspension or emulsion comprises not less than 0.28% by weight of said compound.

8. The method according to claim 1 wherein the compound is present in an amount greater than 5 mg.

Assignees

• Univ Iowa Res Found

Inventors

• Adams Christopher M
• Dyle Michael C
• Welsh Michael

Classifications

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A61K31/58 Primary

  containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin (digitoxin {A61K31/7048}) · CPC title

• A23K20/121

  containing oxygen or sulfur as hetero atom · CPC title

• C12Q1/6883

  for diseases caused by alterations of genetic material · CPC title