Systems and methods for neurological traffic and/or receptor functional evaluation and/or modification

Patent metadata

Field	Value
Publication number	US-10004458-B2
Application number	US-201414780068-A
Country	US
Kind code	B2
Filing date	Mar 27, 2014
Priority date	Mar 27, 2013
Publication date	Jun 26, 2018
Grant date	Jun 26, 2018

Abstract

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

First claim

What is claimed is:

1. A guidewire, comprising:
an elongate body dimensioned for insertion into a lumen within a body; and
a sensing tip electrically and mechanically coupled to the elongate body, configured to interface with the wall of the lumen, the sensing tip configured to convey one or more electrophysiological signals associated with an electrophysiological activity in the vicinity of an anatomical site of interest within the vicinity of the lumen;
wherein the guidewire is configured to monitor the electrophysiological activity;
wherein the sensing tip comprises:
a flexible substrate dimensioned to form a base and two or more tines extending from the base;
a plurality of electrodes formed on the two or more tines of the flexible substrate;
one or more microcircuits formed on the base of the flexible substrate;
one or more conducting traces formed on the flexible substrate providing electrical interconnection between the one or more microcircuits and the plurality of electrodes; and
one or more interconnects for coupling at least one of the one or more microcircuits formed on the base of the flexible substrate with one or more power and signal lead wires; and

wherein the flexible substrate is rolled to form the sensing tip.

2. The guidewire in accordance with claim 1 , wherein the plurality of electrodes are dimensioned and configured to interface with the anatomical site of interest upon placement thereby.

3. The guidewire in accordance with claim 1 , wherein the plurality of electrodes are configured to measure one or more electrophysiological signals related to one or more of water concentration, tone, evoked potential, remote stimulation of nervous activity, an electromyographic signal, a mechanomyographic signal, a local field potential, an electroacoustic event, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity, central sympathetic drive, tissue tone, nerve traffic, or combinations thereof.

4. The guidewire in accordance with claim 1 , wherein the sensing tip is dimensioned and configured for placement into a parenchyma of an organ coupled with the lumen.

5. The guidewire in accordance with claim 4 , wherein the sensing tip is dimensioned and configured for placement into at least one of a renal cortex of a kidney, an adrenal gland, an adrenal medulla, an adrenal cortex, and a renal pelvis of a kidney.

6. The guidewire in accordance with claim 1 , wherein the sensing tip is configured such that at least one of the plurality of electrodes comprised therein is substantially isolated from a fluid within the lumen upon deployment of the sensing tip within the lumen by an isolation layer selectively applied to one or more regions of the sensing tip.

7. The guidewire in accordance with claim 1 , wherein the sensing tip is configured such that at least one of the plurality of electrodes comprised therein maintains contact with a wall of the lumen during a procedure upon deployment of the sensing tip within the lumen.

8. The guidewire in accordance with claim 1 , wherein at least one of the plurality of electrodes substantially maintains contact with the wall of the lumen while the sensing tip is dragged along the interior thereof, after deployment of the sensing tip within the lumen.

9. The guidewire in accordance with claim 1 , wherein the sensing tip is configured such that at least one of the plurality of electrodes is embedded into a wall of the lumen upon deployment of the sensing tip within the lumen.

10. The guidewire in accordance with claim 1 , wherein the guidewire is coupled to a second surgical device, the second surgical device configured to perform at least one of an ablation procedure and a stimulation procedure within the body.

11. The guidewire in accordance with claim 10 , wherein the second surgical device provides a reference electrode electrically coupled with at least one of the plurality of electrodes comprised within the guidewire.

12. The guidewire in accordance with claim 1 , wherein at least one of the microcircuits is configured to convey one or more sensed physiologic signals to a proximal end of the guidewire via the one or more power and signal lead wires.

13. The guidewire in accordance with claim 12 , wherein at least one of the microcircuits is configured to condition one or more of the sensed physiologic signals measured by one or more of the plurality of electrodes prior to conveying the one or more sensed physiologic signals to the proximal end of the guidewire.

14. The guidewire in accordance with claim 12 , wherein at least one of the microcircuits is configured to perform a digital conversion of one or more of the sensed physiologic signals measured by one or more of the plurality of electrodes prior to conveying the one or more sensed physiologic signals to the proximal end of the guidewire.

15. The guidewire in accordance with claim 12 , wherein at least one of the microcircuits is configured to multiplex sensed physiologic signals from two or more of the plurality of electrodes comprised within the guidewire prior to conveying the sensed physiologic signals to the proximal end of the guidewire.

16. The guidewire in accordance with claim 1 , wherein the guidewire further comprises one or more additional electrodes electrically and mechanically coupled with the elongate body, configured to deliver energy to the anatomical site of interest upon placement thereby.

17. The guidewire in accordance with claim 1 , wherein the guidewire comprises one or more microneedles slidingly coupled with the elongate body, configured so as to be deployed beyond the elongate body into the anatomical site of interest upon placement thereby.

18. The guidewire in accordance with claim 17 , wherein at least one of the one or more microneedles comprises a lumen through which a substance may be delivered to the anatomical site of interest upon deployment of the microneedle there into.

19. The guidewire in accordance with claim 18 , wherein the substance is one of a neurotoxin, a cancer treating agent, a neuroblocking agent, a neurostimulating agent, a neurodepressant, a vasodilator, a vasoconstrictor, glucose, insulin, a combination thereof, and a formulation of the substance with a delivery vehicle.

20. The guidewire in accordance with claim 18 , wherein at least one of the one or more microneedles comprises one or more electrodes for at least one of sensing, stimulating, and ablating the anatomical site of interest upon deployment of the microneedle there into.

21. The guidewire of claim 1 , wherein the guidewire comprises a diameter one of less than 1 mm, less than 0.75 mm, less than 0.5 mm, and less than 0.25 mm.

22. A system for neuromodulating an anatomical site in a vicinity of a lumen, comprising:
a subsystem configured to perform a surgical procedure on the anatomical site;
a guidewire configured to monitor electrophysiological activity within a parenchyma of an organ coupled to the lumen and to generate one or more signals therefrom; and
a control unit configured to accept signals from the guidewire, and to at least one of: adjust the surgical procedure dependent upon the signals; display the signals; evaluate the surgical procedure dependent upon the signals; plan a surgical path dependent upon the signals; and determine the extent of the procedure dependent upon the signals;
wherein the guidewire comprises:
an elongate body dimensioned for insertion into a lumen within a body; and
a sensing tip electrically and mechani

Assignees

• Autonomix Medical Inc

Inventors

• Toth Landy
• Schwartz Robert

Classifications

• A61B2018/00511

  Kidney · CPC title

• A61B2018/0022

  Balloons · CPC title

• A61B2090/064

  for measuring force, pressure or mechanical tension · CPC title

• A61B5/201

  Assessing renal or kidney functions · CPC title

• A61B90/06

  Measuring instruments not otherwise provided for · CPC title