Controlled sympathectomy and micro-ablation systems and methods

Patent metadata

Field	Value
Publication number	US-9649064-B2
Application number	US-201514638832-A
Country	US
Kind code	B2
Filing date	Mar 4, 2015
Priority date	Jan 26, 2012
Publication date	May 16, 2017
Grant date	May 16, 2017

Abstract

A catheter system for controlled sympathectomy procedures is disclosed. A catheter system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed.

First claim

What is claimed is:

1. A system, comprising:
a tool comprising:
a delivery catheter;
one or more microfingers having substantially elongate structures;
a plurality of sensing tips electrically and mechanically coupled to the one or more microfingers, the plurality of sensing tips configured to interface with a wall of a lumen coupled to an organ of a subject on deployment of the one or more microfingers from the delivery catheter; and
a local control circuit embedded in the substantially elongate structure of at least one of the one or more microfingers; and

a feedback system coupled to the tool;
wherein the tool is configured:
to apply a procedure to a first region in a vicinity of the lumen via delivery of at least one of energy and a chemical to at least one of the plurality of sensing tips under control of the local control circuit; and
to apply a follow on procedure to a second region in the vicinity of the lumen via delivery of at least one of energy and a chemical to at least one of the plurality of sensing tips under control of the local control circuit, the second region being located equidistant or closer to the organ than the first region;
to monitor one or more physiologic parameters of the subject utilizing at least one of the plurality of sensing tips after application of the follow on procedure;
to condition one or more signals representing the monitored physiologic parameters utilizing the local control circuit; and
to convey the conditioned one or more signals representing the monitored physiologic parameters to the feedback system;

wherein the feedback system is configured:
to receive the conditioned one or more signals representing the monitored physiologic parameters;
to analyze the received signals to determine one or more changes in the physiologic parameters; and
to convey an outcome of the procedure to an operator based upon the determined changes in the physiologic parameters.

2. The system in accordance with claim 1 , wherein the feedback system is configured to indicate to the operator a successful outcome for the procedure if one or more of the physiologic parameters do not substantially change during a predetermined period following application of the follow on procedure.

3. The system in accordance with claim 1 , wherein the feedback system is configured to indicate to the operator an unsuccessful outcome for the procedure if one or more of the physiologic parameters substantially change during a predetermined period following application of the follow on procedure.

4. The system in accordance with claim 1 , wherein at least one of the first region and the second region substantially surround the circumference of the lumen.

5. The system in accordance with claim 1 , wherein the procedure is selected from the group consisting of an ablation, an excision, a cut, a burn, a radio frequency ablation, freezing, a microwave ablation, radiosurgery, an ultrasonic ablation, an abrasion, a biopsy, and delivery of a substance.

6. The system in accordance with claim 1 , wherein the follow on procedure is selected from the group consisting of an ablation, an excision, a cut, a burn, a radio frequency ablation, freezing, a microwave ablation, radiosurgery, an ultrasonic ablation, an abrasion, a biopsy, stimulation, and delivery of a substance.

7. The system in accordance with claim 1 , wherein the one or more physiologic parameters are selected from water concentration, tone, blood oxygen saturation of local tissues, evoked potential, electrolyte or solute concentration, stimulation of nervous activity, sensing of nervous activity, electromyography, temperature, blood pressure, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity (MSNA), central sympathetic drive, a mechanomyographic signal, a local field potential, an electroacoustic event, central sympathetic drive, tissue tone, nerve traffic, and combinations thereof.

8. The system in accordance with claim 2 , wherein the predetermined period is longer than 5 seconds (s), longer than 30 s, longer than 1 minute (min), longer than 3 min, longer than 5 min, or longer than 8 min.

9. The system in accordance with claim 1 , wherein a timespan between application of the procedure and application of the follow on procedure is longer than 5 s, longer than 30 s, longer than 1 min, longer than 3 min, longer than 5 min, or longer than 8 min.

10. The system in accordance with claim 1 , wherein the tool is further configured to apply one or more subsequent follow on procedures to one of the first region and the second region of the subject under control of the local control circuit based on feedback received from the feedback system.

11. The system in accordance with claim 10 , wherein the feedback system is configured to indicate to the operator a durable outcome for the procedure if one or more of the physiologic parameters do not substantially change during a predetermined period following application of the one or more subsequent follow on procedures.

12. The system in accordance with claim 1 , wherein one or more of the plurality of sensing tips are sized and dimensioned to be deliverable to and to interface with at least one of the first region and the second region.

13. The system in accordance with claim 1 , wherein the plurality of sensing tips comprise a balloon catheter comprising a balloon with a surface, the balloon shaped and dimensioned for placement within the lumen, the balloon comprising one or more energy elements and chemical delivery elements arranged along the surface thereof, the one or more energy elements and chemical delivery elements configured to perform at least one of the procedure and the follow on procedure.

14. The system in accordance with claim 1 , further comprising one or more sensors, separate from the tool, configured to monitor one or more physiologic parameters of the subject.

15. The system in accordance with claim 14 , wherein at least one of the sensors is a pressure sensor sized to fit within a lumen in the body, configured to measure a blood pressure response therefrom.

16. The system in accordance with claim 1 , wherein the system performs at least one of a denervation and a neuromodulation procedure in the vicinity of a renal artery.

17. The system in accordance with claim 1 , wherein the system assesses the durability of at least one of a denervation and a neuromodulation procedure.

18. The system in accordance with claim 1 , wherein the one or more microfingers comprise a longitudinal wire cage configured to maintain contact with the wall of the lumen without inhibiting flow of fluids through the lumen.

19. The system of claim 18 , wherein the tool further comprises a guidewire configured to assist with guiding the longitudinal wire cage to the first region and the second region.

20. The system of claim 19 , wherein the tool further comprises a distal ringlet configured to accommodate passage of the guidewire through the longitudinal wire cage.

21. The system of claim 18 , wherein the longitudinal wire cage is configured such that a first microfinger array comprising a first subset of the plurality of sensing tips biases against the wall of the lumen in the first region while a second microfinger array comprising a second subset of the plurality of sensing tips biases against the wall of the lumen in the second region during a single placement of the tool.

22. The system of claim 1 , wherein the one or more microfingers comprise a first microfing

Assignees

• Autonomix Medical Inc

Inventors

• Toth Landy
• Schwartz Robert

Classifications

• A61B5/24

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• A61B18/02

  by cooling, e.g. cryogenic techniques · CPC title

• A61B2018/00434

  Neural system · CPC title

• A61B2018/1467

  using more than two electrodes on a single probe · CPC title

• A61B5/04001

  Human Necessities · mapped topic