Treatment of otitis media

Patent metadata

Field	Value
Publication number	US-10000577-B2
Application number	US-201515510942-A
Country	US
Kind code	B2
Filing date	Sep 11, 2015
Priority date	Sep 11, 2014
Publication date	Jun 19, 2018
Grant date	Jun 19, 2018

Abstract

A method of treating otitis media in a subject is described that includes administering to the subject a therapeutically effective amount of an Actin-Related Protein 2/3 Complex (Arp2/3) inhibitor. The role of Arp2/3 in otitis media was identified using comprehensive proteomic and metabolomic studies of otitis media using the chinchilla model.

First claim

What is claimed is:

1. A method of treating otitis media in a subject, comprising administering to the subject a therapeutically effective amount of an Actin-Related Protein 2/3 Complex (Arp2/3) inhibitor.

2. The method of claim 1 , wherein the Arp2/3 inhibitor is small molecule organic compound.

3. The method of claim 2 , wherein the Arp2/3 inhibitor is selected from the group consisting of CK-636, CK-666, CK-548, and CK-869.

4. The method of claim 1 , wherein the subject has a bacterial infection.

5. The method of claim 4 , wherein the bacterial infection is infection by Haemophilus influenzae.

6. The method of claim 1 , further comprising administration of an antibiotic.

7. The method of claim 6 , wherein the antibiotic is selected from the list consisting of amoxicillin, rifampicin, ciprofloxacin, azithromycin, clarithromycin, ceftriaxone, cefuroxime, and cefotaxime.

8. The method of claim 1 , wherein the Arp2/3 inhibitor is an antibody that specifically binds to Arp2/3.

9. The method of claim 1 , wherein the Arp2/3 inhibitor is administered together with a pharmaceutically acceptable carrier.

10. The method of claim 1 , wherein the otitis media is selected from the group consisting of recurrent acute otitis media (RAOM), chronic otitis media with effusion (COME), acute post-tympanostomy otorrhea (APTO), and chronic suppurative otitis media (CSOM).

11. The method of claim 1 , wherein the subject is human.

Assignees

• Res Inst Nationwide Childrens Hospital

Inventors

• Justice Sheryl S
• Mason Kevin M
• Harrison Alistair

Classifications

• C07D409/12

  linked by a chain containing hetero atoms as chain links · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61K31/426

  1,3-Thiazoles · CPC title

• A61K31/4045

  Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin · CPC title

• A61P31/04

  Antibacterial agents · CPC title