Microbiome identification and bacteriophage formulations
US-2024123002-A1 · Apr 18, 2024 · US
US9977020B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9977020-B2 |
| Application number | US-201615019520-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 9, 2016 |
| Priority date | Aug 28, 2009 |
| Publication date | May 22, 2018 |
| Grant date | May 22, 2018 |
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Chimera proteins including: (i) at least one sequence of a DbpA protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii , and (ii) at least one sequence of an OspC protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii . Also, a method and a kit for the in vitro diagnosis of Lyme borreliosis using said proteins.
Opening claim text (preview).
The invention claimed is: 1. A chimeric polypeptide comprising (i) a first amino acid sequence comprising any of the amino acid sequences of SEQ ID Nos: 1, 3, 5 and 6, and (ii) a second amino acid sequence comprising any of the amino acid sequences of SEQ ID Nos: 2, 4 and 7. 2. The polypeptide as claimed in claim 1 , comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. 3. The polypeptide as claimed in claim 1 , comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. 4. The polypeptide as claimed in claim 1 , comprising the amino acid sequences of SEQ ID NO: 5 and SEQ ID NO: 7. 5. The polypeptide as claimed in claim 1 , comprising the amino acid sequences of SEQ ID NO: 6 and SEQ ID NO: 7. 6. The polypeptide as claimed in claim 1 , comprising the amino acid sequences of SEQ ID NO: 5, SEQ ID NO: 6, and SEQ ID NO: 7. 7. A diagnostic kit comprising the polypeptide as claimed in claim 1 . 8. The diagnostic kit as claimed in claim 7 , further comprising an anti-human-immunoglobulin labeled with a label. 9. The diagnostic kit as claimed in claim 7 , further comprising a chimeric Variable Lipoprotein Surface-Exposed (VlsE) polypeptide.
Immunostimulants · CPC title
containing a tag for immunodetection, or an epitope for immunisation · CPC title
against anti-bacterial Ig · CPC title
Bacteria · CPC title
from bacteria · CPC title
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