Methods and Compositions for Generating Bioactive Assemblies of Increased Complexity and Uses
US-2015374846-A1 · Dec 31, 2015 · US
Compositions and method for multiplex biomarker profiling
USRE50754E · US · E1
| Field | Value |
|---|---|
| Publication number | US-RE50754-E |
| Application number | US-202217861032-A |
| Country | US |
| Kind code | E1 |
| Filing date | Jul 8, 2022 |
| Priority date | Apr 25, 2011 |
| Publication date | Jan 20, 2026 |
| Grant date | Jan 20, 2026 |
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Abstract
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Provided herein are compositions and methods for identifying or quantitating one or more analytes in sample. The composition can comprise an affinity molecule reversibly conjugated to a label moiety via a double-stranded nucleic acid linker or via an adaptor molecule. The affinity molecule and the label moiety can be linked to different strands of the double-stranded nucleic acid linker. Compositions can be used in any biological assays for detection, identification and/or quantification of target molecules or analytes, including multiplex staining for molecular profiling of individual cells or cellular populations. For example, the compositions can be adapted for use in immunofluorescence, fluorescence in situ hybridization, immunohistochemistry, western blot, and the like.
First claim
Opening claim text (preview).
What is claimed is: 1 . A composition comprising a plurality of affinity molecules, wherein: (i) each member of the plurality binds a target, wherein each affinity molecule is conjugated via hybridized first and second nucleic acid strands to a label moiety, wherein detectable properties of the label moieties are distinguishable from one another, wherein the targets are distinguishable from one another, wherein the hybridized first nucleic acid strands are distinguishable from o…
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Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Physics · mapped topic
- G01N33/588Primary
Physics · mapped topic
- C12Q1/6841Primary
Chemistry & Metallurgy · mapped topic
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- What does patent USRE50754E cover?
- Provided herein are compositions and methods for identifying or quantitating one or more analytes in sample. The composition can comprise an affinity molecule reversibly conjugated to a label moiety via a double-stranded nucleic acid linker or via an adaptor molecule. The affinity molecule and the label moiety can be linked to different strands of the double-stranded nucleic acid linker. Compos…
- Who is the assignee on this patent?
- Univ Washington Through Its Center For Commercialization, The Univ Of Washington Through Its Center For Commercialization
- What technology area does this patent fall under?
- Primary CPC classification G01N33/588. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jan 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (E1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).