Capsule device having variable specific gravity

Patent metadata

Field	Value
Publication number	US-RE48181-E
Application number	US-201816233134-A
Country	US
Kind code	E1
Filing date	Dec 27, 2018
Priority date	Mar 17, 2015
Publication date	Sep 1, 2020
Grant date	Sep 1, 2020

Abstract

An endoscopy capsule having an image collecting capacity includes a deformable member configured to inflate when exposed to body liquid. The deformable member includes an effervescent material. When the effervescent reacts with water the resulting Carbon-Dioxide gas reduces the specific gravity of the endoscopy capsule. The capsule is contained within a shell or dome when swallowed. The shell or dome is configured dissolve in either a low or high pH environment.

First claim

What is claimed is:

1. A capsule endoscope, comprising:
a sensor system comprising a light source, an image sensor for capturing image frames of a scene illuminated by the light source;
a housing adapted for being swallowed, wherein the housing encloses the sensor system; and
at least one pouch containing an effervescent, the pouch being attached to the housing and being semi-permeable or porous, permeable to body liquid but not to gas so that the effervescent is able to generate gas upon contact with the body liquid;
wherein at least the pouch is encapsulated within a dissolvable shell, dome or coating, and wherein specific gravity (SG) of the capsule endoscope is greater than 1 when the pouch is encapsulated within the dissolvable shell, dome or coating and wherein the SG of the capsule endoscope corresponds to a specific gravity of all the components of the capsule endoscope collectively together; and
wherein the capsule endoscope said at least the pouch is configured to control estimated inflation and deflation periods of the capsule endoscope said at least the pouch such that the capsule endoscope has the SG of the capsule endoscope greater than 1 for a first period of time, and less than 1 for a second period of time following the first period of time; and
wherein the capsule endoscope said at least the pouch is configured to control estimated inflation and deflation periods of the capsule endoscope said at least the pouch by properly selecting parameters from a parameter group comprising a combination of pouch membrane type and pouch wall thickness to affect a rate of diffusion of body liquid into the pouch.

2. The capsule endoscope of claim 1 , wherein at least the pouch is encapsulated within an enteric shell, dome or coating.

3. The capsule endoscope of claim 2 , wherein the enteric shell, dome or coating is designed to dissolve a pH in range of 5.0-7.4 so that the enteric shell, dome or coating is intended to disintegrate in the small intestine or the cecum.

4. The capsule endoscope of claim 2 , wherein the capsule endoscope is configured to cause the specific gravity (SG) of the capsule endoscope drops below 1 in about 2-6 hours after the capsule endoscope is exposed to bodily fluids by swallowing the capsule endoscope.

5. The capsule endoscope of claim 2 , wherein the endoscope is configured such that the specific gravity (SG) of the capsule endoscope is more than 1 for more than about six hours after the capsule endoscope is exposed to bodily fluids by swallowing the capsule endoscope.

6. The capsule endoscope of claim 2 , wherein the pouch has a wall thickness of less than 2 mils for one a first group of pouch materials or less than 5 mils for another a second group of pouch materials.

7. The capsule endoscope of claim 2 , wherein the pouch is configured such that the specific gravity (SG) of the capsule endoscope is more than 1 for more than 1.5 hours after the pouch is exposed to bodily liquids by swallowing the capsule endoscope.

8. The capsule endoscope of claim 2 , wherein the pouch is configured such that the specific gravity (SG) of the capsule endoscope is less than 1 for more than 2 or 4 hours after the pouch is exposed to bodily liquids by swallowing the capsule endoscope.

9. The capsule endoscope of claim 1 , wherein the endoscope is configured such that the specific gravity (SG) of the capsule endoscope drops below 1 in about 2-6 hours after the capsule endoscope is exposed to bodily fluids by swallowing.

10. The capsule endoscope of claim 1 , wherein the endoscope is configured such that the specific gravity (SG) of the capsule endoscope is less than 1 for more than about six hours after the capsule endoscope is exposed to bodily fluids by swallowing the capsule endoscope.

11. The capsule endoscope of claim 1 , wherein the pouch comprises is selected from a set consisting of polyetherblockamide copolymers, thermoplastic polyurethanes, polyamides, polyamide block copolymers, polyamide elastomers, polyurethanes, polyesters, polyester copolymers, polyamide copolymers, polyurethane copolymers, polyether copolymers, polyesteramides, polyesteramide copolymers, polyvinyl chloride, polyvinyl chloride copolymers, polyvinylidene dichloride, polyvinylidene dichloride copolymers, fluoropolymers, polyvinyl fluoride, polyvinyl fluoride copolymers, polyvinylidene difluoride, polyvinylidene difluoride copolymers, polyvinylpyrrolidone copolymers, or and polyvinylalcohol copolymers.

12. The capsule endoscope of claim 1 , wherein the pouch has a wall thickness of less than 5 mils or less than 10 mils.

13. The capsule endoscope of claim 1 12, wherein the pouch water uptake in 12 hours relative to a pouch and effervescent dry weight is less than 200% for one a first group of pouch materials or 50% for another a second group of pouch materials.

14. The capsule endoscope of claim 13 , wherein the pouch material is selected from a set consisting of polyetherblockamide copolymers, thermoplastic polyurethanes, polyamides, polyamide block copolymers, polyamide elastomers, polyurethanes, polyesters, polyester copolymers, polyamide copolymers, polyurethane copolymers, polyether copolymers, polyvinyl chloride, polyvinyl chloride copolymers, polyvinylidene dichloride, polyvinylidene dichloride copolymers, fluoropolymers, polyvinyl fluoride, polyvinyl fluoride copolymers, polyvinylidene difluoride, or and polyvinylidene difluoride copolymers.

15. The capsule endoscope of claim 1 , wherein the Young's modulus of the pouch is:
high enough to create a non-conformal pouch; or
low enough to create a slightly conformal pouch, such that the pouch can reach a maximum size 25% above the nominal size with a maximum of 40 mg effervescent.

16. The capsule endoscope of claim 1 , wherein the pouch is configured such that the specific gravity (SG) of the capsule endoscope is more than 1 for more than 1.5 hours after the pouch is exposed to bodily liquids by swallowing the capsule endoscope.

17. The capsule endoscope of claim 1 , wherein the pouch is configured such that the specific gravity (SG) of the capsule endoscope is less than 1 for more than 2 or 4 hours after the pouch is exposed to bodily liquids by swallowing the capsule endoscope.

18. The capsule endoscope of claim 1 , wherein the pouch is configured such that the specific gravity (SG) is of the capsule endoscope is less than 1 for more than 4 hours but less than 12 hours after the pouch is exposed to bodily liquids by swallowing the capsule endoscope.

19. The capsule endoscope of claim 1 , wherein the effervescent is coated.

20. The capsule endoscope of claim 16 19, wherein the effervescent coating is an enteric coating designed to a pH in the range of 5.0-7.4 such that the effervescent is intended to react with water after the endoscope has reached the small intestine.

21. The capsule endoscope of claim 1 , wherein the pouch further comprises a desiccant.

22. The capsule endoscope of claim 21 , wherein the ratio of desiccant to effervescent is 1:10 to 2:1 by weight.

23. The capsule endoscope of claim 1 , wherein the pouch has a total exterior surface area of about 300 and 1,000 mm 2 .

24. The capsule endoscope of claim 23 , wherein between about 10 mg and 50 mg of effervescent are contained within the pouch.

25. The capsule endoscope of claim 1 , wherein specific gravity (SG) of the capsule endoscope is greater than 1 again for a third period of time following the second peri

Assignees

• Capsovision Inc

Inventors

• Trollsas Mikael
• Trinh Phat
• Hadley Mark
• Wang Kang-Huai
• Wilson Gordon Cook
• Lu Ganyu

Classifications

• A61B1/00148

  using anchoring means · CPC title

• A61B1/2736

  Gastroscopes · CPC title

• A61B5/073

  Intestinal transmitters · CPC title

• A61B5/14539

  for measuring pH · CPC title

• A61B1/041 Primary

  Capsule endoscopes for imaging · CPC title