Methods and compositions for wound treatment

Patent metadata

Field	Value
Publication number	US-RE46584-E
Application number	US-201615006882-A
Country	US
Kind code	E1
Filing date	Jan 26, 2016
Priority date	Dec 21, 2010
Publication date	Oct 24, 2017
Grant date	Oct 24, 2017

Abstract

The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.

First claim

What is claimed is:

1. A method for treatment of an open wound in a subject,
comprising administering to the open wound a composition comprising a carrier containing a hemostatic active agent, and a wound targeting moiety comprising an antibody specific for actin,
wherein the carrier is conjugated to the antibody, and
wherein the antibody facilitates local delivery of the hemostatic active agent to wound tissue by binding to an exposed actin protein, wherein the exposed actin protein is exposed upon wounding of the subject.

2. The method of claim 1 , wherein the antibody binds to an exposed intracellular actin protein.

3. A method for treatment of an internal wound in a subject, comprising administering to the subject a composition comprising a carrier containing a hemostatic active agent and displaying a wound targeting moiety comprising an antibody specific for actin, wherein the antibody facilitates local delivery of the hemostatic active agent to injured tissue by binding to an intracellular actin protein that is exposed by displacement from its natural location.

4. The method of claim 3 , wherein the intracellular actin protein is exposed by cell lysis or rupture.

5. The method of claim 1, wherein the administering is performed by irrigating the wound with the composition.

6. The method of claim 3, wherein the administering is performed by intravenous delivery of the composition.

7. The method of claim 3, wherein the administering is performed by oral delivery of the composition.

8. The method of claim 3, wherein the administering is performed by inhalation of the composition.

Assignees

• Leidos Inc

Inventors

• Dresios John
• Griffey Richard Holmes

Classifications

• A61K39/44

  Antibodies bound to carriers · CPC title

• A61K47/6801

  Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61K47/6847

  the antibody targeting a hormone or a hormone-releasing or -inhibiting factor · CPC title

• A61K38/02

  Peptides of undefined number of amino acids; Derivatives thereof · CPC title