TARGET-BASED METHOD FOR HIGH-THROUGHPUT AND SUBCLASS SPECIFIC IgG GLYCAN PROFILING IN HUMAN PLASMA
US-2024353417-A1 · Oct 24, 2024 · US
Optimized FC variants
USRE45992E · US · E1
| Field | Value |
|---|---|
| Publication number | US-RE45992-E |
| Application number | US-201014338413-A |
| Country | US |
| Kind code | E1 |
| Filing date | Mar 19, 2010 |
| Priority date | Mar 20, 2009 |
| Publication date | May 3, 2016 |
| Grant date | May 3, 2016 |
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- Title
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Abstract
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A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.
First claim
Opening claim text (preview).
The invention claimed is: 1. A variant of a parent polypeptide comprising a Fc region, which variant exhibits increased binding to FcRn as compared to said parent polypeptide and comprises a combination of amino acid modifications selected from the group consisting of: N315D/A330V/N361D/A378V/N434Y, V264E/N315D/A378V/N390S/G420R/N434Y, N315D/A378V/N434Y, N315D/A330V/A378V/N434Y, N315D/K334E/A378V/N434Y, V264E/N315D/A378V, P228R/N315D/A330V/N361D/A378V/N434Y, P228R/P230S/N315D/A330V/N361D/A378V/N434Y, P228L/N315D/A330V/N361D/A378V/N434Y, P228L/P230S/N315D/A330V/N361D/A378V/N434Y, P230S/N315D/A330V/N361D/A378V/N434Y, P230T/V264E/N315D/K370R/A378V, of the Fc region, wherein the numbering of the amino acids in the Fc region is that of the EU index as in Kabat. 2. The variant according to claim 1 , wherein said variant is an antibody. 3. The variant according to claim 2 , wherein said antibody is an IgG antibody. 4. A pharmaceutical composition comprising a variant as defined in claim 1 . 5. A medicament comprising a variant according to claim 1 . 6. An isolated nucleic acid encoding a variant as defined in claim 1 . 7. A vector comprising the nucleic acid of claim 6 . 8. An isolated host cell containing the vector of claim 7 . 9. A method for producing a variant according to claim 1 , comprising culturing a host cell containing a vector comprising an isolated nucleic acid encoding said variant so that the nucleic acid is expressed. 10. A variant according to claim 1, wherein the Fc region of the parent polypeptide is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4.
Assignees
Inventors
Classifications
Drugs for immunological or allergic disorders · CPC title
Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title
Drugs for disorders of the blood or the extracellular fluid · CPC title
Immunosuppressants, e.g. drugs for graft rejection · CPC title
Drugs for disorders of the nervous system · CPC title
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Frequently asked questions
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- What does patent USRE45992E cover?
- A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.
- Who is the assignee on this patent?
- Lab Francais Du Fractionnement
- What technology area does this patent fall under?
- Primary CPC classification C07K16/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 03 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (E1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).